Prdx1与肿瘤

The relationship between Prdx1 and carcinoma

Prdx1(peroxiredoxin 1)属于过氧化物氧化还原酶蛋白(peroxiredoxin,Prdx)家族成员,是一类在对抗活性氧簇(ROS)、抗氧化过程中发挥关键作用的蛋白质,在多种肿瘤组织中高表达,其表达与肿瘤细胞增殖、分化、转移、复发及放化疗的敏感性密切相关。本文就Prdx1的结构、在肿瘤中的生物学功能及其信号调控机制等进行综述,为寻找新的肿瘤生物治疗靶点提供依据。

Peroxiredoxin 1（Prdx1）belongs to peroxide oxidoreductase protein（peroxiredoxin, Prdx）family,which is over-expressed in multiple cancers and it play an important role in antagonizing reactive oxygen species （ROS） therefore as works as anti-oxidations. Its expression is closely related with tumor proliferation, differentiation and metastasis as well as with sensibility to radiotherapy and chemotherapy. Its structure and biological function in tumors and regulation mechanism were reviewed in this paper. It can provide evidence to screen new therapeutic targets in the treatment of tumors.