摘要
促血管生成因子不仅参与实体肿瘤的发生和进展,而且与非实体瘤(如白血病等)的发生和发展进程密切相关.在众多促血管生成因子中,血管生成素(angiogenin,ANG)可以促进实体瘤细胞的生长和血管生成,然而其引起血管生成异常的详细机制目前还不完全清楚.本文就近年来在非实体瘤中血管生成素的功能及其潜在的治疗作用的研究进展进行综述.
Angiogenic factors have been widely implicated in the formation and progression of solid tumors. A number of angiogenic mediators have been recently appreciated as having equivalent function in non-solid tumors, such as leukemia. One such factor, angiogenin (ANG) , promotes tumor cell growth and angiogenesis in solid cancers ; however its precise function (s) in hematological disorders are not fully understood. This review summarizes current knowledge of the function and therapeutic potential of angiogenic factors, with particular emphasis on the role and hypothesized mechanism of ANG in a non- solid tumor setting.
出处
《中国生物化学与分子生物学报》
CAS
CSCD
北大核心
2015年第12期1267-1275,共9页
Chinese Journal of Biochemistry and Molecular Biology
基金
Supported by NIH grants F31HL128127(KAG)
R01CA105241(GFH)
R01NS065237(GFH)
Sackler Dean’s Fellow Award(KAG)
Sackler Families Collaborative Cancer Biology Award(KAG/GFH)~~