血管生成素在造血系统恶性肿瘤中的作用及机制（英文）

Mechanism and Function of Angiogenin in Hematopoietic Malignancy

促血管生成因子不仅参与实体肿瘤的发生和进展,而且与非实体瘤(如白血病等)的发生和发展进程密切相关.在众多促血管生成因子中,血管生成素(angiogenin,ANG)可以促进实体瘤细胞的生长和血管生成,然而其引起血管生成异常的详细机制目前还不完全清楚.本文就近年来在非实体瘤中血管生成素的功能及其潜在的治疗作用的研究进展进行综述.

Angiogenic factors have been widely implicated in the formation and progression of solid tumors. A number of angiogenic mediators have been recently appreciated as having equivalent function in non-solid tumors, such as leukemia. One such factor, angiogenin （ANG） , promotes tumor cell growth and angiogenesis in solid cancers ; however its precise function （s） in hematological disorders are not fully understood. This review summarizes current knowledge of the function and therapeutic potential of angiogenic factors, with particular emphasis on the role and hypothesized mechanism of ANG in a non- solid tumor setting.