我院多囊卵巢综合征药物处方分析

Analysis of Polycystic Ovary Syndrome Prescriptions in Our Hospital

目的:为多囊卵巢综合征治疗药物的合理使用提供参考。方法:统计我院2013年1-12月多囊卵巢综合征治疗药物的销售金额和用药频度(DDDs)等,并进行排序,依据相应规范和药品说明书等资料分析处方合理性。结果:多囊卵巢综合征处方共1 551张,涉及76种药物,总销售金额为181 072.90元;药品种类以激素相关药物(处方频次占比81.37%,销售金额占比73.51%)和中成药(处方频次占比15.41%,销售金额占比19.43%)为主。激素相关药物DDDs排名前5位的是炔雌醇环丙孕酮片、盐酸二甲双胍肠溶片、黄体酮胶丸、地屈孕酮片和黄体酮软胶囊;中成药DDDs排名前5位的是坤泰胶囊、右归胶囊、还少胶囊、加味逍遥胶囊和女金胶囊。处方中单药使用率为72.08%;不合理用药处方比例为1.69%。结论:我院多囊卵巢综合征用药总体合理。个别处方存在不合理情况,主要表现在临床诊断不全和用法用量不合理,药师需加强对处方的审查与干预。

OBJECTIVE：To provide reference for rational use of polycystic ovary syndrome（PCOS）drugs. METHODS：The utilization of PCOS drugs in our hospital during Jan.-Dec. 2013 were analyzed in respects of consumption sum,DDDs,sorting and so on. The rationality of prescription was analyzed according to guidelines and drug package inserts and so on. RESULTS：There were 1 551 prescriptions,involving 76 kinds of drugs,and their total consumption sum was 181 072.90 yuan. Main types of drugs were hormone related drugs（accounting for 81.37% of prescription frequency,73.51% of consumption sum）and Chinese patent medicine（accounting for 15.41% of prescription frequency,19.43% of consumption sum）. Top 5 hormone drugs in the list of DDDs were Ethinylestradiol and Cyproterone acetate tablets,Metformin hydrochloride enteric-coated tablets,Progesterone soft capsule,Dydrogesterone tablets and Progesterone soft capsules. Top 5 Chinese patent medicines in the list of DDDs were Kuntai capsule,Yougui capsule,Huanshao capsule,Jiawei xiaoyao capsule and Nvjin capsule. Single drug accounted for 72.08% in prescription. The proportion of irrational drug use was 1.69%. CONCLUSIONS：The application of drug in patients with PCOS is reasonable generally. Some prescriptions are unreasonable,mainly manifesting as incomplete clinical diagnosis,irrational usage and dosage. Pharmacists should strengthen prescription verification and intervention.