我院2014年癌痛病房阿片类镇痛药使用分析

Analysis of the Utilization of Opioids Analgesics for Cancer Pain in Inpatient Department of Our Hospital in 2014

目的:为阿片类镇痛药的合理使用提供参考。方法:抽取2014年我院癌痛病房患者阿片类镇痛药处方1 882张,以限定日剂量(DDD)作为药物利用情况的客观指标,以药物利用指数(DUI)作为药物评价的判断指标,分析其使用情况。结果:我院当年癌痛病房阿片类镇痛药处方中病种分布最多的为肺癌,占42.19%。常用药物有硫酸吗啡缓释片、盐酸羟考酮缓释片等,其DUI都<1.0。药物使用数量、销售金额排名第1位的均为硫酸吗啡缓释片;药物剂型主要为片剂、注射剂及贴剂,其中片剂所占构成比最大,达到97.30%。结论:我院在使用阿片类镇痛药治疗癌痛时,在用药种类、剂型、给药途径上基本合理规范,但阿片类镇痛药使用剂量偏小,各类药物的DUI均<1,同时还存在着一定数量的不合理处方。

OBJECTIVE：To provide reference for rational use of opioids analgesics. METHODS：1 882 prescriptions of opioids analgesics for cancer pain collected from our hospital in 2014 were analyzed by defined daily dose（DDD）and drug utilization index（DUI）. RESULTS：The diseases of opioids analgesics prescriptions for cancer pain in our hospital in 2014 were mainly lung cancer,accounting for 42.19%. Commonly used opioids analgesics included Morphine sulfate sustained-release tablets,Oxycodone Hydrochloride sustained-release tablets and so on,and their DUI were all below 1.0. Top one drug in the list of amount and consumption sum was Morphine sulfate sustained-release tablets,and its main dosage form were tablets,injection and patches,in which tablets occupied the largest proportion,reaching 97.30%. CONCLUSIONS：The application of opioids analgesics for cancer pain in our hospital is basically rational in terms of drug types,dosage form and route of administration,but the dose of opioids analgesics is small and their DUI is lower than 1;at the same time,there are a few irrational prescription.