磁共振波谱MEGA-PRESS序列检测正常人纹状体γ-氨基丁酸

Measurement of corpus striatumγ-aminobutyric acid concentrations by MEGA-PRESS sequence of magnetic resonance spectroscopy in normal human

目的探讨磁共振波谱MEGA-PRESS序列定量检测纹状体γ-氨基丁酸(GABA)浓度的可行性及年龄、性别、脑内区域差异与纹状体GABA浓度的关系。方法招募117名健康的志愿者,对其行三维MP-RAGE序列扫描,并进行冠状位、矢状位、轴位图像重建。ROI定位于双侧纹状体,行MEGA-PRESS序列波谱扫描。将扫描数据导入LCModel软件行自动分析,获取3.0ppm处的GABA含量。结果最终符合LCModel数据标准者共103名。志愿者总体左、右侧GABA浓度均随年龄增长而减低(F=17.429、10.415),男性志愿者左、右侧(F=9.459、6.666)和女性志愿者左、右侧(F=8.479、3.457)GABA浓度分别随年龄增长而减低,差异均有统计学意义(P均<0.01)。男、女性志愿者左侧与右侧GABA浓度(t=0.471、0.891)及志愿者总体左侧与右侧GABA浓度(t=0.483),差异均无统计学意义(P均>0.05)。结论正常人纹状体GABA浓度随年龄增长而减少,不同性别GABA含量相等,GABA呈左右对称性分布。

Objective To study the feasibility of MEGA-PRESS sequence of magnetic resonance spectroscopy by quantitatively detecting γ-aminobutyric acid（GABA） of corpus striatum.Besides,to explore the relationship among the gender age and the amount of GABA in corpus striatum.Methods A total of 117 healthy volunteers were recruited.Three-dimentional MP-RAGE sequence was acquired for coronal sagittal and axial orientations for exact planning.Volumes of interest were located in the corpus striatum region.Then the datas were imported into LCModel software,acquired the GABA content at 3.0 ppm by MEGA-PRESS sequence.Results All 103 volunteers were conformed to LCModel data standard.Concentration of GABA in left right corpus striatum decreased with aging（F= 17.429,10.415） in tatal volunteers（P〈0.01）.Concentration of GABA in left right corpus striatum decreased with aging in male volunteers（F =9.459,6.666）and female volunteers（F = 8.479,3.457） with statistical differences（all P〈0.01）.There were no statistical difference between left and right corpus striatum for GABA concentration in male and female volunteers（t=0.471,0.891,both P〈0.05）,as well as that in total volunteers（t=0.483,P〉0.05）.Conclusion GABA concentrations of corpus striatum in normal human will decrease with aging.The different sexes have the same GABA concentrations.GABA is distributed symmetrically on the left and right sides.