性激素与原发性尿路结石形成关系的研究

Research on the relationship between sex hormones and primary urinary stone formation

目的：探讨性激素与原发性尿路结石形成的关系,尿路结石发病性别差异的原因以及外源性使用雌激素药物的安全性。方法：将我院1995年3月-2014年3月诊治的355例符合入组标准的患有尿路结石及同质的未患有尿路结石的患者纳入本研究,清晨空腹、安静状态下分别采取各组患者的肘静脉血液送检,采用化学发光法分别测取送检标本的雌二醇（E2）、睾酮（T）、孕酮（Prog）、催乳素（PRL）、黄体生成激素（LH）、卵泡刺激素（FSH）,对比分析。结果：E2、T、Prog、PRL、LH、FSH在各组中差异均有统计学意义,但卵泡刺激素在男性组中差异不显著。结论：1雌性激素可能对原发性尿路结石有一定的抑制作用,而睾酮可能促进尿路结石的形成;2适度使用外源性雌激素药物治疗及预防尿路结石尤其是绝经后女性患者的尿路结石是有效的。

Objective： To investigate the causal relationship between sex hormone and primary urinary stone formation, the cause of gender differences in urinary tract stone formation and the safety of exogenous estrogen drugs. Method： From March 1995 to March 2014, 355 cases were studied including patients diagnosed as urinary tract stones and other homogeneous patients who were not diagnosed as urinary tract stones. Each patient was taken elbow venous blood samples when they fast and were under quiet state in the morning. Chemiluminescence method was used to measure estradiol （E2）, testosterone （T）, progesterone （Prog）, prolactin （PRL）, luteinizing hormone （LH）, and follicle stimulating hormone （FSH） in each sample, and related data were comparatively analysed. Result： E2, T, Prog, PRL, LH, FSH showed statistically significant in each group, but the difference of FSH in male group was not significant. Conclusion： ①Female hormones may have inhibitory effect on primary urinary stones, but testosterone may promote the formation of urinary calculi. ②A rational use of exogenous estrogen in treatment and prevention of urinary calculi is effective especially in postmenopausal women.