哮喘急性发作期应用孟鲁司特前后外周血IL4及IFN-γ水平变化及意义

Change and significance of peripheral blood IL-4 and IFN-γ levels before and after montelukast in treatment of acute attack of asthma

目的 观察哮喘急性发作期应用孟鲁司特前后外周血白细胞介素-4（IL-4）、y干扰素（IFN-γ）水平变化并分析其意义.方法 回顾性分析漯河市中心医院2012年3月至2013年8月收治的100例哮喘急性发作期患者的病理资料,随机的分为对照组和治疗组,每组50例,对照组采取常规治疗,治疗组应用孟鲁斯特治疗,借助于ELISA法对哮喘急性发作期应用孟鲁司特前后外周血IL-4、IFN-y水平变化进行检测.结果 治疗后两组患者外周血IL-4均低于治疗前,且治疗组较对照组降低较为明显;两组治疗后IFN-γ水平均升高,且治疗组较对照组升高较为明显,两组比较差异有统计学意义（P＜0.05）.结论 哮喘急性发作期患者应用孟鲁斯特治疗,其免疫调节功能调节较为明显,对于哮喘发作有控制作用,值得在哮喘急性发作临床治疗中加以推广.

Objective To observe the change of peripheral blood IL-4 and IFN-γ levels before and after montelukast in treatment of acute attack of asthma and to analyze the significance.Methods To retrospectively analyze the pathological data of 100 cases of acute attack of asthma in Luohe central hospital from March 2012 to August 2013, they were randomly divided into treatment group and control group, with 50 cases in each group, the control group received routine treatment, the treatment group were treated with montelukast, the changes of peripheral blood IL-4 and IFN-γ levels before and after treatment were detected by ELISA.Results After treatment, the peripheral blood IL-4 levels in both groups decreased than before treatment, and the treatment group decreased significantly than that in control group;the IFN-γ levels increased in both groups after treatment, and the treatment group increased significantly than that in control group, the differences were significant （P 〈 0.05）.Conclusions Montelukast in treatment of patients with acute attack of asthma has obvious immune regulation function, and has control function on asthma it is worth to be promoted in acute asthma clinical treatment.