妊娠性糖尿病及合并高血压患者血中D-二聚体水平检测研究

D-dimer levels detection in patients with gestational diabetes and high blood pressure

目的 探讨妊娠性糖尿病合并高血压患者检测血中D-二聚体水平的临床价值.方法 选取大同市中医医院2013年9月至2014年8月收治的妊娠性糖尿病患者116例作为研究对象,回顾性分析其临床资料.按照高血压并发症分为两组,A组68例合并高血压,B组48例为单纯妊娠性糖尿病.选取同期于我院体检的健康孕妇45例作为C组,对A、B、C组的血D-二聚体水平予以检测,探讨其临床价值.结果 A组血浆D-二聚体水平显著高于B、C两组,差异有统计学意义（P＜0.05）;B组高于C组,差异有统计学意义（P＜0.05）.按照血压水平将A组患者划分为轻度妊高征、中度妊高征以及重度妊高征,重度妊高征显著高于轻度、中度,对比差异有统计学意义（P＜0.05）;中度妊高征显著高于轻度,对比差异有统计学意义（P＜0.05）.结论 对于妊娠性糖尿病合并高血压患者可在早期检测其D-二聚体水平,不仅可早期诊断妊高征还可评估疗效且判断预后,具有重要临床价值.

Objective To investigate the clinical value of detection D-dimer levels in patients with gestational diabetes and hypertension.Methods Selected 116 cases of patients with gestational diabetes from September 2013 to August 2014 as study objects, and retrospectively analyzed the clinical data.Divided them into two groups according to complications of hypertension, 68 patients with hypertension in group A and 48 cases of gestational diabetes alone in group B.Select 45 cases of healthy pregnant women as a group C from the same period in our hospital.Detected the D-dimer levels in the three groups and explore its clinical value.Results Plasma D-dimer level in group A was significantly higher than that in group B and group C, the differences were significant （P 〈 0.05）;that of group B was higher than that of group C, the difference was significant （P 〈 0.05）.The cases in group A were classified as mild preeclampsia, moderate and severe pregnancy according to the blood pressure levels, the preeclampsia was significantly higher than that of mild, moderate and the differences were significant （P 〈0.05）;mild to moderate PIH significantly higher, compared to the difference was significant （P 〈0.05）.Conclusions To patients with gestational diabetes mellitus and hypertension, detection of D-dimer levels at an early stage not only can early diagnose pregnancy-induced hypertension and can also diagnose the prognosis, so it has important clinical value.