蒙药材细叶铁线莲化学成分研究

Study on the Chemical constituents of a Traditional Mogolian Medicine HERBA CLEMATIS

目的:研究蒙药材细叶铁线莲(HERBA CLEMATIS)中主要化学成分。方法:利用正、反相柱色谱,凝胶色谱LH20和制备型HPLC等方法,对芹叶铁线莲(Clematis aethusaefolia Turcz.)干燥地上部分的水提取物进行分离纯化;得到的单体化合物经过高分辨质谱(HRMS)、核磁共振(1D、2D-NMR)等光谱方法,鉴定其平面结构和立体构型。结果:从细叶铁线莲水提取物中分离得到6个化合物,分别鉴定为二氢去氢二聚松柏醇(1),丁香脂素(2),松脂素(3),表松脂素(4),里立脂素B二甲醚(5)和黑麦草内酯(6)。结论:所有化合物均为首次从该植物中分离得到。

This study was aimed to isolate and characterize of chemical constituents in a traditional Mongolian medicine HERBA CLEMATIS. Normal and reverse phase coloumn chromatography, gel filtration chromatography sephadex LH-20, and preparative HPLC were used for isolation and purification compounds from the water extraction of the arial part of C. aethusaefolia Turcz. The planar structures and spatial configurations of isolated compounds were identified by high resolution MS, 1D and 2D NMR, and other spectrographic methods. The chemical research on the Mongolian medicine results 6 compounds, dihydrodehydrodiconiferyl alcohol（1）, syringaresinol（2）, pinoresinol（3）, epi-pinoresinol（4）, lirioresinol B dimethyl ether（5） and loliolide（6）. All the compounds were isolated from this plant for the first time.