实验室监测指标对评估儿童重症肺炎病情及预后意义的研究进展

Advances in the roles of biomarkers in evaluating the severity and prognosis of severe pneumonia in children

肺炎是引起5岁以下儿童死亡的首要原因。全世界每年约有200万小于5岁的儿童死于肺炎，占该人群总死亡人数的19％。根据2008年的调查，所有的肺炎患儿中，有7％－13％属于重症肺炎。目前重症肺炎的早期诊治往往存在困难，本文综述重症肺炎患儿脑利钠肽、D－二聚体、C－反应蛋白、血乳酸水平、血清锌、降钙素原、前白蛋白、血小板计数、内皮素－1以及高迁移率族蛋白1等实验室监测指标的研究进展，以期能够提高重症肺炎的早期诊断水平及预后认识。

Pneumonia is the primary cause of death in children under five-years old. About 2 million children younger than 5 years die of pneumonia each year worldwide, accounting for 19% of the total number of deaths. According to the survey in 2008,7% to 13% of the children with pneumonia were severe pneumonia. Currently, the early diagnosis and treatment of severe pneumonia is often difficult. In order to improve the early diagnosis an prognosis cognition level of severe pneumonia,here is to make a review on the recent literatures on the biomarkers like brain natriuretic peptide, D-Dimer, C-reactive protein, lactate, zinc, procalcitoin, prealbumin, platelet count, endothelin-1 and high mobility group box 1 in children with severe pneumonia.