帕利哌酮联合无抽搐电痉挛治疗对精神分裂症患者记忆力的影响研究

The Effects of Paliperidone combined Non-convulsive Electroconvulsiue Therapy in Patients with Schizophrenia

目的探讨帕利哌酮联合无抽搐电痉挛治疗方法对于精神分裂症患者记忆力的影响。方法本文以精神分裂症患者为研究对象,病例来源于我院精神科,共120例患者,随机平均分为甲组、乙组和丙组。甲组患者选用单一帕利哌酮药物治疗,乙组患者选用单一无抽搐电痉挛治疗,丙组患者选用帕利哌酮联合无抽搐电痉挛治疗方法治疗。比较三组患者的治疗总有效率,治疗前、治疗后1d、1周、1个月、2个月时的记忆力评估情况。结果甲组与乙组治疗效果相当,丙组治疗效果优于其他两组患者,差异有统计学意义(P<0.05);丙组患者经帕利哌酮联合无抽搐电痉挛方法治疗1d时记忆力有所下降,与甲组患者的记忆力评估结果比较时差异有统计学意义(P<0.05),与乙组患者比较时差异无统计学意义(P>0.05),治疗1周即恢复,与乙组患者差异有统计学意义(P<0.05)。结论帕利哌酮联合无抽搐电痉挛治疗精神分裂症时,患者虽有记忆力下降情况,但可快速恢复,且治疗效果显著。

Objective To investigate paliperidone Conbined non-convulsive ECT for memory of schizophrenia patients.Methods A total of 120 schizophnenia patients were randomly divided into three groups,Group A,Group B and Group C. Group A patients a single paliperidone drug treatment,group B patients accepted a single non-convulsive ECT treatment,group C patients accepted paliperidone therapy combined with non-convulsive ECT. Total effective rate and memory score before treatment,1 day,a week,a month,two months were compared. Results The effeet of Group A and Group B were rather,Group C was better than the other two groups,the difference was significant,P〈 0. 05,statistically significant. After treatment 1 day,group C memory declined significantly than group（ P 〈0. 05）,After 1 weeks of treatment group C memony recoveried. Conclusion Paliperidone joint no ECT in the seizures treatment of schizophrenia disease,although patients with memory loss situation,but can be quickly restored,and the treatment effect was remarkable.