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颅内动脉粥样硬化斑块稳定性的高分辨率核磁共振成像研究进展 被引量：15

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摘要 颅内动脉粥样硬化（intracranial atherosclerosis,ICAS）是脑卒中的主要病因[1],中国46.6％的急性缺血性脑卒中均由ICAS导致[2],且与其相关的缺血性脑血管事件的年复发风险高达17.1％ ～ 38.2％[3-4].如今,随着颅内、外动脉粥样硬化高分辨率磁共振成像（high resolution MRI,HRMRI）的相关研究[5-8]日益深入,研究者发现HRMRI可有效辨别动脉粥样硬化斑块的形态、成分和评估斑块的稳定性.探讨动脉粥样硬化引发脑卒中的病理生理机制,可以达到预测缺血性脑卒中风险、指导早期预防治疗并减少脑卒中发生的目的.鉴于此,我们就ICAS斑块稳定性的HRMRI研究进展作一综述.
作者 王婷婷 吴军
机构地区 北京大学深圳医院神经内科
出处 《中华神经科杂志》 CAS CSCD 北大核心 2015年第12期1115-1121,共7页 Chinese Journal of Neurology
关键词 颅内动脉粥样硬化 高分辨率磁共振成像 斑块稳定性 核磁共振成像 急性缺血性脑卒中 动脉粥样硬化斑块 病理生理机制 ICAS
分类号 R743 [医药卫生—神经病学与精神病学]
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参考文献58

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同被引文献94

  • 1Sasitorn Petcharunpaisan,Joana Ramalho,Mauricio Castillo.Arterial spin labeling in neuroimaging[J].World Journal of Radiology,2010,2(10):384-398. 被引量：23
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  • 3Wang Y, Zhao X , Liu L, et al. Prevalence and outcomes of symptomaticintracranial large artery stenoses and occlusions in China : theChinese Intracranial Atherosclerosis ( CICAS ) Study [J]. Stroke,2014,45(3) :663-669.
  • 4Wong KS, Li H. Long-term mortality and recurrent stroke risk amongChinese stroke patients with predominant intracranial atherosclerosis[J], Stroke,2003 ,34(10) :2361-2366.
  • 5Zhao DL,Deng G,Xie B , et al. High-resolution MRI of the vesselwall in patients with symptomatic atherosclerotic stenosis of the middlecerebral artery [J]. Journal of Clinical Neuroscience, 2015,22(4) :700-704.
  • 6Kim JM, Jung KH, Sohn CH, et al. Intracranial plaque enhancementfrom high resolution vessel wall magnetic resonance imaging predictsstroke recurrence [J] . International Journal of Stroke ,2016,11 (2 ) :171-179.
  • 7Xu P , Lv L, Li S , et al. Use of high-resolution 3. 0-T magnetic resonanceimaging to characterize atherosclerotic plaques in patients withcerebral infarction [J]. Experimental and Therapeutic Medicine,2015,10(6) :2424-2428.
  • 8Underhill HR, Hatsukami TS, Cai J , et al. A noninvasive imaging approachto assess plaque severity : the carotid atherosclerosis score[J] . AJNR American Journal of Neuroradiology ,2010,31(6) : 10681075.
  • 9Moody AR, Murphy RE, Morgan PS, et al. Characterization of complicatedcarotid plaque with magnetic resonance direct thrombus imagingin patients with cerebral ischemia [J] . Circulation, 2003,107 (24) :3047-3052.
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引证文献15

二级引证文献74

中华神经科杂志
2015年 第12期

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