慢性再生障碍性贫血患者易感染状态相关性分析

Correlation between chronic aplastic anemia and susceptible state of infections

目的探讨慢性再生障碍性贫血与易感染状态相关性,为临床治疗提供有效治疗手段。方法选取2010年4月-2015年4月于医院收治的慢性再生障碍性贫血患者60例,对所有患者填写统一制定的感染回顾调查表,详细记录患者过去半年内临床资料,对结果进行相关分析,所有数据采用SPSS 19.0软件进行统计分析。结果半年内感染次数<3次患者的Hb、N显著高于半年内感染次数>3次患者,差异有统计学意义(P<0.05);同时感染部位<2部位患者的Hb、N、WBC显著高于同时感染部位>2部位患者,差异有统计学意义(P<0.05);平均感染时长<10d患者的Hb、N、WBC显著高于平均感染时长>10d患者,差异有统计学意义(P<0.05);单纯细菌感染患者的N显著高于合并侵袭性真菌感染患者,差异具有统计学意义(P<0.05)。结论慢性再生性障碍贫血患者的Hb、N与自身易感性、感染程度以及感染类别呈正相关。

OBJECTIVE To explore the relationship between the chronic aplastic anemia and the susceptible state of infections so as to provide guidance for effective clinical treatment. METHODS A total of 60 patients with chronic aplastic anemia who were treated in the hospital from Apr 2010 to Apr 2015 were enrolled in the study, then the unified questionnaires for infections were filled out by all the patients, the clinical data of the patients were recorded in detail in the past half year, the correlative analysis of the results was carried out, and the statistical analysis of data was performed with the use of SPSS 19.0 software. RESULTS The levels of Ha and N of the patients in- fected less than 3 times within half a year were significantly higher than those of the patients infected more than 3 times within half a year, and there was significant difference （P〈0.05）. The levels of Hb, N, and WBC of the patients with less than 2 infection sites were significantly higher than those of the patients with more than 2 infection sites, and there was significant difference （P〈0.05）. The levels of Hb, N, and WBC of the patients with the average duration of infections less than 10 days were significantly higher than those of the patients with the average duration of infections more than 10 days, and there was significant difference （P〈0.05）. The level of N of the patients with single bacterial infection was significantly higher than that of the patients complicated with invasive fungal infection, and there was significant difference （P〈0.05）. CONCLUSION The levels of Hb and N of the patients with chronic aplastic anemia are positively correlated with the susceptibility, degree of infection, and type of infection.