人乳头状瘤病毒多重感染与宫颈癌患者病理特征的关系

Relationship between HPV multiple infections and pathological characteristics in patients with cervical cancer

目的研究宫颈癌患者人乳头状瘤病毒(HPV)多重感染与临床病理特征的关系,为临床预防提供理论参考。方法选取2005年4月-2014年4月医院收治的130例宫颈癌患者,应用导流杂交基因芯片技术诊断和分型HPV感染,数据采用SPSS 17.0软件进行统计分析。结果 130例宫颈癌患者中HPV感染92例,感染率为70.8%,单一感染79例感染率为60.8%,多重感染13例感染率为10.0%;单一感染患者的基因型主要为HPV16、18、58,而多重感染患者的基因型主要是HPV16+58/52;无论是多重感染还是单一感染,HPV16型均是主要类型;年龄≥52岁的宫颈癌患者以HPV的多重感染比例显著高于<52岁患者,两者比较差异有统计学意义(P<0.05);而在病理分型、临床分期以及淋巴结转移上,HPV单一感染和多重感染之间比较差异无统计学意义。结论宫颈癌患者HPV多重感染和年龄有关,但是和病理类型、临床分期以及淋巴结转移无关。

OBJECTIVE To study the relationship between human papilloma virus （HPV） multiple infections and clinical pathological characteristics in patients with cervical cancer, so as to provide theoretical basis for clinical prevention. METHODS Totally 130 cases of patients with cervical cancer in Apr. 2005 to Apr. 2014 in our hospital were selected. The flow-through hybridization and gene chip technology was used for diagnosis and genotyping of HPV infections. The software SPSS 17.0 was used for statistical analysis of data. RESULTS Among the 130 cases of patients, 92 cases had HPV infections, the infection rate in 70.8% ; 79 cases had single infection, the infection rate was 60.8% 13 cases had multiple infections, the infection rate was 10%. The genotypes of single infection were mainly HPV16, HPV18, and HPV58, and the main genotype of multiple infections was HPV16＋ 58/52. The HPV multiple infections rate in patients with age ≥52 was significantly higher than that with age 52 years （P〈0.05）; while in the pathological type, clinical stage and lymph node metastasis, the difference between HPV single infection and multiple infection had no significance. CONCLUSION HPV multiple infections of patients with cervical cancer is related to age, but it has no relationship with the pathological types, Clinical stages and lymph node metastasis.