抗磷脂抗体谱的临床应用和规范检测

Clinical application and standardization of antiphosphoUpid antibodies tests

抗磷脂综合征（APS）诊断标准明确将抗磷脂抗体（aPLs）的检测纳入其诊断标准，说明aPLs的检测对于APS的诊断意义重大。在过去的十几年中，对于如何提高aPLs的检测水平，如何实现aPLs的标准化进行了大量的工作。然而由于aPLs存在显著的异质性，aPLs的检测方法标准化程度较低以及不同实验室间检测结果一致性较差，一定程度限制了aPLs检测以及其临床应用。本文着重讨论aPLs的临床应用与检测规范，探讨如何建立aPLs检测的标准化体系以更好地提高aPLs的临昧捡泓。

According to the consensus criteria of antiphospholipid syndrome（ APS）, the diagnosis of APS requires the persistent presence of antiphospholipid antibodies （aPLs）, indicating the critical role of aPLs in the diagnosis of APS. During the last decade, great efforts have been made to improve the laboratory detection and standardization of aPLs testing. Unfortunately, the heterogeneous nature of aPLs, lacking of standardization in aPLs test, and significant inter-laboratory variation have hampered the clinical application of aPLs test. In this commentary, the clinical application and standardization of aPLs test are focused on, and how to establish the standardization system in aPLs test in order to improve the performance of aPLs test in clinical practice are discussed.