纤溶酶原受体与相关疾病的分子机制

Molecular Mechanisms of Plasminogen Receptors and Associated Diseases

纤溶酶原(PLG)经激活为纤溶酶(PLM)后,除了发挥纤溶和栓溶作用,还广泛参与胚胎发育、组织重构、伤口愈合等生理过程.近年来研究显示:PLM还与炎症、自身免疫、肿瘤和神经变性等存在紧密联系,而且已在细胞表面发现十几种PLG受体(PLGR)、结合蛋白.我们综述了这些受体和结合蛋白的结构、信号通路和致病机制方面的研究进展,从而为进一步理解纤溶系统的功能、发展新的诊疗方法提供思路.

Plasmin （PLM）, via activation from plasminogen （PLG）, not only exerts fibrinolysis and thrombolysis effects, but also involves in extensive physical processes such as embryonic development, tissue remodeling and wound healing. Moreover, recent studies showed a tough association between PLM with inflammation, autoimmunity, malignancy and neural degeneration. Furthermore, more than ten plasminogen receptors and binding proteins have been discovered on cellular surface. Here, we review the researching progresses on the structures, signal transduction and pathogenic mechanisms of these receptors and binding proteins, so as to provide clues for better understanding on fibrinolysis system and for developing new diagnostic and therapeutic pathways.