杭州6～12岁儿童口腔幽门螺杆菌感染现状及危险因素分析

Current status and risk factors of oral Helicobacter pylori infection among children aged 6-12 years in Hangzhou City

目的调查杭州本地区6-12岁儿童口腔幽门螺杆菌（Helicobacterpylori，lip）感染现状，并进行危险因素分析。 方法对2012-2014年因胃肠道症状首次就诊于杭州市西溪医院的380例6-12岁患儿用唾液测试板法检测口腔H_D，并对患儿家长进行问卷调查；同期因其他疾病人院的380例儿童按年龄、性别1：1匹配作为对照。 结果760名研究对象，Up阳性人数为330名（43．6％），研究组380名患儿阳性率50．8％高于对照组36．1％（P〈0．05），男性患儿阳性率49．0％高于女性37．6％（P〈0。05）；阳性率随着年龄增加升高（P〈0．05）；Hp相关知识总知晓率20．8％，研究组总知晓率18．4％低于对照组23．2％（P〈0．05）；不良卫生习惯（OR=2．141，95％C／=1．409 3．885）、杯筷和牙缸共用（OR=1．677，95％C／=1．284-2．873）、养宠物（OR=1．389，95％C／=1．210-1．826）是Hp感染的独立危险因素。 结论6-12岁儿童口腔幽门螺杆菌阳性率较高、知识知晓率较低，口腔卫生习惯不良、共用杯筷和牙缸、养宠物是rip感染的危险因素。

Objective To investigate the prevalence of oral Helicobacter pylori （Hp） infection in children aged between 6 and12 years in Hangzhou City, and to analyze its risk factors. Methods Saliva test board method was used to detect oral Hp in380 children aged 6 to 12 years firstly coming to Xixi Hospital of Hangzhou City for gastrointestinal disease from 2012 to 2014;meanwhile, their parents received a questionnaire survey. 380 children matched by gender and age （1：1） visiting the hospital atthe same time for other diseases served as the controls. Results Among the 760 research subjects, 330 （43.6 % ） were Hp -positive. Hp - positive rate was higher in the study group than in the control group （50.8% vs. 36.1%, P〈0.05）. Moreover,Hp - positive rate was higher in male patients than in female ones （49.0 % vs. 37.6 %, P 〈 0.05）. Pip - positive rate increasedalong with the increasing age （P 〈 0.05）. The total awareness rate of Hp- related knowledge was 20.8 %. The total awarenessrate of the study group was lower than that of the control group （18.4% vs. 23.2%, P〈0.05）. Poor health habits （OR =2. 141, 95 % CI = 1. 409 - 3. 885）, sharing cups and tooth sets （ OR = 1. 677, 95 % CI = 1. 284 - 2. 873） and keeping pets （ OR= 1. 389, 95 % CI = 1. 210 - 1. 826） were the independent risk factors for Hp infection. Conclusions Children aged 6 - 12years have a high Hp infection rate but a low knowledge awareness rate. Poor health habits, sharing cups and tooth sets andkeeping pets are the risk factors for Hp infection.