摘要
目的:观察血管内皮生长因子(VEGF)与胎盘生长因子(PLGF)在孕早、中期的妊娠期高血压(HDCP)患者的表达,为诊断妊娠期高血压提供依据。方法:选择46例正常妊娠(正常妊娠组)和39例HDCP(HDCP组)患者作为研究对象,HDCP组又分为:妊娠高血压期(26例)、轻度子痫前期(8例)和重度子痫前期(5例),采用酶联免疫吸附法(ELISA)检测各组早、中、晚期血清VEGF与PLGF水平,并进行比较。结果:与正常妊娠组比较,HDCP组孕中期(24周)血清VEGF[(187.54±17.36)ng/L比(123.35±16.46)ng/L]与PLGF[(217.49±26.32)ng/L比(128.32±21.23)ng/L]水平明显降低(P均<0.01),且孕晚期(34周)血清VEGF和PLGF水平下降更显著(P<0.01);在HDCP组中,孕24周时,与妊娠期高血压和重度子痫前期比较,轻度子痫前期PLGF[(127.46±16.55)ng/L、(158.40±26.33)ng/L比(99.02±27.26)ng/L]水平明显下降;且34周时VEGF和PLGF水平下降更显著(P<0.05或<0.01)。结论:妊娠高血压患者孕中期血清VEGF与PLGF水平降低有助于妊娠高血压的早期诊断。
Objective: To observe expressions of vascular endothelial growth factor (VEGF) and placental growth factor (PLGF) in patients with hypertensive disorder complicating pregnancy (HDCP) during early and mid pregnancy, and pro- vide basis for diagnosing HDCP. Methods: A total of 46 normal pregnant women (normal pregnancy group) and 39 HDCP patients (HDCP group) were enrolled. The HDCP group was further divided into gestational hypertension group (n = 26), mild preeclampsia group (n = 8) and severe preeclampsia group (n = 5). Enzyme linked immunosorbent assay (ELISA) was used to measure serum VEGF and PLGF levels during early, mid and late pregnancy, and those were compared among a- bove groups. Results: Compared with normal pregnancy group, there were significant reductions in serum levels of VEGF [ (187. 54±17. 36) ng/L vs. (123.35±16.46) ng/L] and PLGF [ (217. 49±26. 32) ng/L vs. (128. 32±21.23) ng/L] in HDCP group during mid period (24th week), P〈0.01 all, and serum VEGF and PLGF levels more significantly reduced during late pregnancy (34th week) (P〈0.01); in HDCP group, compared with gestational hypertension group and severe preeclampsia group, PLGF level [ (127. 46 ± 16. 55) ng/L, (158. 40± 26. 33) ng/L vs. (99.02±27.26) ng/L] significantly reduced in mild preeclampsia group on 24th week; the serum VEGF and PLGF levels more significantly reduced on 34th week, P〈0. 05 or 〈0.01. Conclusion: Reduced serum levels of VEGF and PLGF during mid pregnancy in HDCP patients are help to early diagnosing HDCP.
出处
《心血管康复医学杂志》
CAS
2015年第6期623-626,共4页
Chinese Journal of Cardiovascular Rehabilitation Medicine
关键词
高血压
妊娠性
血管内皮生长因子类
子痫
Hypertension, pregnancy-induced
Vascular endothelial growth factors
Eclampsia