基于离子液体微乳液淀粉纳米微球载药性和释药性研究

Study on drug loading and release properties of starch nanoparticles in ionic liquid based microemulsion

该文以可溶性淀粉为原料,以溴化1–十六烷基–3–甲基咪唑(C16mim Br)和正丁醇为表面活性剂,采用W/O微乳液交联法制备淀粉纳米微球。然后以淀粉纳米微球为载体,广谱性抗肿瘤药物盐酸米托蒽醌为模型药物,采用物理吸附法,以载药量和包封率为评价指标,对载药时间、载药温度和药物浓度进行优化筛选,并且对载药淀粉纳米微球的体外释药性能进行评价。实验表明:载药温度、载药时间和药物浓度对淀粉纳米微球的载药量和包封率有极大的影响,在载药时间为2 h、载药温度为27℃、盐酸米托蒽醌浓度为0.08 mg/m L时,包封率达到最大值,为23.7%。当释药时间达到10 h时,淀粉纳米微球的体外累积释药率达85.53%,因此其具有良好的释药性能。

In this research,starch nanoparticles were prepared by water in oil（W/O）microemulsion cross–linkingmethods with soluble starch asmaterial,C16mimBr and n–butyl alcohols as surfactants. Then the drug loading and entrapment efficiency of starch nanoparticles were investigated by physical adsorptionmethod with starch nanoparticles ascarrier andmitoxantrone hydrochloride as drug model,to simulate the influence of loading time,loading temperature and drugconcentration,and the drug release in vitro was evaluated.The results showed that loading time,loading temperature and drugconcentration had a great impact on drug loading property and entrapment efficiency of starch nanoparticles. When loading time,temperature and drugconcentration were 2 h,27℃ and 0.08mg/mL, respectively,entrapment efficiencycame to a relative high degree,which was 23.7%. When the drug release time was 10 h,the accumulation release rate in vitro reached 85.53%,which indicated good drug release properties.