丙种球蛋白与抗生素联用治疗脑卒中引起肺部感染的临床研究

Clinical Research of Gamma Globulin Combined with Antibiotic Treatment of Stroke Caused Lung Infection

目的:通过探讨丙种球蛋白与抗生素联用治疗脑卒中引起肺部感染的临床疗效,旨在为临床快速清除病菌、提高患者生活质量提供理论依据。方法:选择2014年1月-2015年1月在本院接受治疗的脑卒中引起肺部感染患者130例,按照随机数字表法分成研究组和对照组,每组各65例。对照组单纯应用抗生素治疗,研究组应用丙种球蛋白联合抗生素治疗,比较两组治疗前后的症状体征积分、神经功能缺损积分、自我生活能力评分、中性粒细胞百分比、住院时间、感染灶吸收时间、细菌清除率、死亡率及治疗有效率。结果:研究组治疗后的症状体征积分为(19.42±1.12)分、神经功能缺损积分为(9.75±1.02)分、自我生活能力评分为(80.12±2.03)分、中性粒细胞百分比为(51.17±4.16)%,均显著优于对照组,两组比较差异均有统计学意义(P<0.05);研究组的住院时间为(26.82±1.74)d、感染灶吸收时间为(7.36±1.02)d、细菌清除率为92.31%、死亡率为3.08%、治疗有效率为90.77%,均显著优于对照组,两组比较差异均有统计学意义(P<0.05)。结论:丙种球蛋白与抗生素联用治疗脑卒中引起的肺部感染,能有效清除细菌、提高治疗效率,对于促进脑卒中患者神经功能及生活能力恢复有重要意义。

Objective：To explore the clinical curative effect of gamma globulin combined with antibiotics in the treatment of stroke caused lung infection, aimed to provide a theoretical basis for quickly remove bacteria and improve the patients’ quality of life.Method：130 patients of lung infection caused by stroke in our hospital were selected from January 2014 to January 2015,they were randomly divided into study group and control group,65 cases in each group.The control group was given antibiotic therapy, the study group was given gamma globulin combined with antibiotic therapy. Before and after treatment,the symptoms score,neurological deficit score,self living ability score,neutral granular cell percentage,hospital time,infection focal absorption time,bacterial clearance rate and mortality and effectively of two groups were compared.Result： After treatment,in the study group, the symptom score was （19.42±1.12）score, neurological deficit score was （9.75±1.02） score,the self living ability score was （80.12±2.03） score, the neutral granular cell percentage was （51.17±4.16）%,the hospital time was （26.82±1.74）d, infection focal absorption time was （7.36±1.02）d, bacterial clearance rate was 92.31%, the mortality rate was 3.08%, the effective rate was 90.77%,they were significantly better than the control group, the differences were statistically significant（P〈0.05）.Conclusion：Gamma globulin and antibiotic treatment of lung infections caused by stroke can effectively remove bacteria,improve treatment efficiency,promote nerve function and viability of stroke patients recover,it has important significance.