冠心病患者血尿酸水平与心功能不全的相关性研究

Correlation Studies between Serum Uric Acid Level and Cardiac Insufficiency of Patients with Coronary Heart Disease

目的：分析血尿酸水平与冠心病慢性心功能不全（CHF）的相关性。方法：将确诊为冠心病的325例患者依据心功能情况分为两组，心功能正常组192例，心功能不全组133例。心功能不全组按纽约心功能分级标准分为Ⅱ~Ⅳ级；采用尿酸氧化酶法测定空腹血尿酸浓度；运用统计学方法分析患者血尿酸浓度与心功能程度的相关性。结果：心功能正常组和心功能不全组患者性别、年龄方面比较差异有统计学意义（P〈0.05）。心功能正常组血尿酸浓度为（325.87±91.32）μmol/L，高尿酸血症（HUA）发生率为20.31%；心功能不全组血尿酸浓度为（424.85±102.23）μmol/L，HUA发生率为48.87%，两组比较差异有统计学意义（P〈0.01）。随着心功能分级的增高，患者的血尿酸浓度逐渐增高，高尿酸血症发生率也逐渐升高，比较差异有统计学意义（P〈0.01）。结论：冠心病心功能不全患者的血尿酸浓度高于心功能正常患者，并随着心功能的下降而不断升高，同时，高尿酸血症发生率也会增加，血尿酸水平与心功能分级呈正相关。

Objective：To analyze correlation between serum uric acid （SUA） and chronic cardiac insufficiency of patients with coronary heart diseases.Method： 325 patients with coronary heart diseases were divided into 2 groups, normal cardiac function group （192 cases） and cardiac dysfunction group （133 cases）. According to the New York Heart Association （NYHA） criteria, 133 cardiac dysfunction patients were divided into Ⅱ-Ⅳ grades. The level of serum uric acid was measured by urate oxidase method. The correlation between the level of serum uric acid and cardiac function was analyzed by statistical method.Result： There were statistically significant differences in sex, age between the two groups （P〈0.05）. The mean serum uric acid level of the normal cardiac function group was （325.87±91.32）μmol/L, and the incidence of hyperuricemia （HUA） was 20.31%. The mean serum uric acid level of the cardiac dysfunction group was （424.85±102.23）μmol/L, and the incidence of HUA was 48.87%. There were statistically significant differences between the two groups （P〈0.01）. With cardiac functional grade increasing,the level of serum uric acid and the incidence of hyperuricemia gradually increased, and there were significant differences （P〈0.01）.Conclusion：The mean serum uric acid level in patients with cardiac dysfunction is higher than patients with normal cardiac function group, and with the decline of cardiac function, the mean serum uric acid level elevated, and the incidence of HUA elevated too. There is a positive correlation between the level of serum uric acid and the cardiac functional grade.