摘要
2-氯苯甲酸经硝化制得2-氯-5-硝基苯甲酸,然后经取代反应制得2-羟基-5-硝基苯甲酸,在锌粉-甲酸肼还原体系下还原硝基制得美沙拉秦,总收率约88%,纯度99.4%。
Mesalazine was synthesized from 2-chlorobenzoic acid by nitrification to give 2-chloro-5-nitrobenzoic acid, which was subjected to substitution by water to give 2-hydroxy-5-nitrobenzoic acid, followed by reduction in the presence of zinc dust and hydrazinium monoformate with an overall yield of about 88 % and an HPLC purity of 99.4 %.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2015年第12期1280-1282,共3页
Chinese Journal of Pharmaceuticals
基金
2014年常州市大学生创新创业训练计划资助项目(常教高[2014]7号)给予资助
