摘要
考察大孔吸附树脂分离纯化结晶母液中3-甲基黄嘌呤的最佳工艺。利用静态吸附试验筛选5种大孔吸附树脂,并通过动态吸附及解吸的单因素影响试验,优选树脂的最佳分离纯化条件。结果表明,大孔吸附树脂HZ16较适用于分离纯化结晶母液中的3-甲基黄嘌呤,其静态吸附量约18 mg/ml。用5%乙醇和60%乙醇(p H 10.0)可以解吸树脂柱上的3-甲基黄嘌呤,平均解吸收率大于92%。
The optimal process was investigated and established for the separation and purification of 3-methylxanthine from crystallization mother liquor with macroporous adsorption resin. Five kinds of macroporous resins were screened by static adsorption test. The optimal purification conditions were obtained based on dynamic adsorption and desorption. The results showed that HZ16 resin was an optimal macroporous adsorbent for the separation and purification of 3-methylxanthine from crystallization mother liquor. Its adsorption capacity for 3-methylxanthine was about 18 mg/ml. 3-Methylxanthine could be effectively desorbed by 5 % and 60 % ethanol （pH 10.0）. The average yield of desorption was over 92 %.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2015年第12期1347-1351,共5页
Chinese Journal of Pharmaceuticals
基金
河北省高等学校科学研究青年基金项目(QN20131108)
关键词
3-甲基黄嘌呤
大孔吸附树脂
吸附
解吸
分离纯化
3-methylxanthine
macroporous adsorption resin
adsorption
desorption
separation and purification
