鼻内镜下鼻腔负压清理联合欧龙马滴剂雾化冲洗治疗放射性鼻窦炎

Nasal endoscope negative pressure cleaning and sinupret drops to treat radiation nasosinusitis

目的:探讨鼻内镜下鼻腔负压清理联合欧龙马滴剂雾化冲洗法在放射性鼻窦炎防治中的应用价值。方法:将153例鼻咽癌患者随机分为A、B、C组进行前瞻性研究,A组采用鼻内镜下行鼻腔负压清理及欧龙马滴剂雾化冲洗,B组在鼻内镜下行鼻腔负压清理及生理盐水雾化冲洗,C组采用经鼻导管生理盐水冲洗鼻腔。分别对所有患者在放疗结束时、放疗结束后3个月、放疗结束后6个月进行鼻窦炎病情评价。结果:组间比较,3个时期放射性鼻窦炎发生率、中重度鼻窦炎发生率均为A组<B组<C组;放疗结束后6个月,A组与C组比较,差异有统计学意义(P<0.01);A组与C组分别与B组比较,差异均有统计学意义(P<0.05)。结论:鼻内镜下鼻腔负压清理联合欧龙马滴剂雾化冲洗法可以明显降低远期放射性鼻窦炎的发生率,尤其是明显降低中重度放射性鼻窦炎的发生率,是一种创新、实用、有效的干预方法。

Objective：To observe the effect of nasal endoscope negative pressure cleaning and sinupret drops to treat radiation nasosinusitis（RNS）.Method：One hundred and fifty-three patients with nasopharyngeal carcinoma were randomly divided into treatment group A,B,C.Group A using nasal endoscope negative pressure cleaning and sinupret drops,group B using nasal endoscope negative pressure cleaning and normal saline spray washing,group C using saline nasal irrigation through nasal catheter.All patients with sinusitis condition were evaluated at the end of radiotherapy,three months and six months after radiotherapy.Result：Comparison between groups,three periods of RNS incidence,moderate to severe RNS incidence are A〈B〈C.Six months after radiotherapy,group A compared with group C,there are significant difference（P〈0.01）,group A and group C compared with group B respectively,the difference was statistically significant（P〈0.05）.Conclusion：Nasal endoscope negative pressure cleaning and sinupret drops can significantly reduce the long-term incidence of RNS,especially obviously reduce the incidence of moderate to severe RNS,which is a practical and effective method to treat RNS.