p38 MAPK与变应性鼻炎的研究进展

The research progress of p38 MAPK and allergic rhinitis

变应性鼻炎（allergic rhinitis,AR）指特应性个体由变应原致敏后由嗜酸粒细胞、肥大细胞和淋巴细胞等多种炎性细胞以及IL-1、2、4、5、6、8、10、12、13、18,IFN-γ等多种细胞因子参与的上气道慢性变态反应性疾病。以鼻痒、鼻塞、阵发性喷嚏及大量清水样鼻涕为主要特征。AR的这些促炎因子及趋化因子的释放、嗜酸粒细胞及肥大细胞的招募以及新生血管生成在AR的发生发展中形成一个恶性循环，目前认为AR是多种细胞共同作用导致的炎症性疾病，是体内免疫细胞群多方面失衡的结果。

Allergic rhinitis is a kind of nasal mucosal chronic noninfectious inflammatory disease,which is caused by an imbalance in the body cytokine network,a number of intracellular signaling pathways being actived.Many studies have shown that mitogen-activated protein kinase（MAPK）involved in the activation process of allergic rhinitis.p38mitogen-activated protein kinase（MAPK）,as one kind of that,plays a key role in the process of inflammatory cells proliferation and differentiation,as well as production of inflammatory cytokines,and involved in airway inflammatory mechanisms of chronic airway disease.In vitro experiments have confirmed that p38 MAPK inhibitors haveanti-inflammatory effect by blocking the downstream related response.