1%吡美莫司乳膏治疗酒渣鼻的临床研究

The effect of 1% Pimecrolimus cream on the patiens with rosacea

目的观察1%吡美莫司乳膏治疗轻中度酒渣鼻的临床疗效及安全性。方法共30例患者,皮损处外搽吡美莫司乳膏,每日早晚各1次,连续使用4周,治疗2周和4周后各随访1次,分别评估治疗前及治疗后酒渣鼻临床积分、总体红斑严重度、研究者总体评价及主观症状严重度指数并进行安全性观察。结果 26例患者完成治疗,酒渣鼻临床积分治疗前为(9.72±1.86),治疗4周后下降至(7.13±2.02);总体红斑严重度的评价治疗前为(1.91±0.59),治疗4周后下降至(1.25±0.88);研究者总体评价治疗前为(3.16±0.94),治疗4周后下降至(2.10±1.18);主观症状严重度指数治疗前为(6.21±0.95),治疗4周后下降至(3.49±1.66)。结论吡美莫司乳膏是治疗轻中度酒渣鼻的一种安全有效的药物,起效较快,有较好的临床使用价值。

Objective To investigate the efficacy and safety of 1% pimecrolimus cream on rosacea. Methods Thirty patients with rosacea were enrolled in this 4-week study of 1% pimecrolimus cream. Patients were topically treated the cream for twice daily. Clinical efficacy was evaluated by a rosacea grading system composed with rosacea clinical score, overall erythema severity, investigator＇s global assessment and subjective severity index. Results The 26 patients who completed the study experienced significantly reduced rosacea clinical scores from （9.72 ± 1.86） at baseline to（7.13±2.02） at the end of treatment （P〈 0.05）. The overall erythema severity decreased from （1.91± 0. 59） at baseline to（ 1.25±0. 88） at week 4 （P〈0.05）. The investigator＇s global assessment decreased from （3.16 ±0. 94） at baseline to （ 2.10± 1.18） at week 4 （P〈 0. 05）. The overall erythema severity decreased significantly from （6.21±0. 95） at baseline to（3.49± 1.66） at week 4 （P〈0. 05）. Conclusion The results of this study suggest that 1% pimecrolimus cream is an rapidly effective and well-tolerated treatment for patients with mild to moderate inflam- matory rosacea.