小花清风藤水提物体内抗流感病毒的研究

Anti-Influenza A Virus Activity of the Extract from Sabia parviflora Wall in Vivo

目的:研究小花清风藤水提物体内抗流感病毒的活性。方法:采用滴鼻感染流感病毒建立BALB/c小鼠肺炎模型,以小鼠存活率、平均存活时间、肺指数、肺组织中病毒滴度及肺组织病理改变为指标,观察不同剂量小花清风藤水提物体内抗流感病毒的活性。结果:与模型组比较,小花清风藤水提物中剂量(i.g,6.5 g/kg)能提高小鼠生存率30%,延长小鼠存活时间,降低小鼠肺指数和肺组织中病毒滴度,明显改善感染小鼠肺组织炎症病变。结论:小花清风藤水提物在体内具有一定的抗流感病毒的作用。

Objective：To investigate the anti-influenza A virus activity of the extract from Sabia parviflora Wall（SPS） in vivo.Methods：The pneumonic model of BALB/c mice were infected by influenza A（HlNl） with nasal drops.The survival rate,lung index,virus titers in lung and pathological changes of lung tissue were determined.Results：Compared with the model group,orally administered SPS at 6.5 g/kg per day for 3 days significantly increased the survival rate,prolonged the mean survival time,reduced the lung index and virus titers in the lung,and relieved the inflammation of lung tissue in infected mice.Conclusion：The extract from S.parviflora Wall exhibit anti-influenza activity in vivo.