乙肝患者HBsAg定量与乙肝病毒DNA定量及谷丙转氨酶水平的相关性研究

Correlation Between HBs Ag Quantitative, HBV- DNA and Alanine Aminotransferase Level in Patients with Hepatitis B

目的:探讨乙型肝炎患者血清中乙肝表面抗原(HBs Ag)定量与乙肝病毒(HBV)DNA定量及谷丙转氨酶(ALT)水平的相关性。方法:收集124例乙肝患者血清,采用化学发光法检测HBs Ag水平,采用实时荧光定量PCR法检测HBV-DNA水平,采用全自动生化分析仪检测ALT水平,分析三者之间的相关性。结果:HBs Ag水平与HBV-DNA含量存在正相关性,HBV-DNA含量与ALT水平存在正相关性,而HBs Ag水平与ALT水平无明显相关性。结论:联合检测3项指标可对乙肝患者HBV感染、复制、传染性以及机体的免疫性做出准确判断。

Objective：To discuss and study the correlation between HBsAg quantitative,hepatitis B virus（HBV）DNA and alanine aminotransferase（ALT） in serum levels in patients with hepatitis B.Methods：124 cases of hepatitis B patients serum were collected,chemiluminescence was used to detect the HBsAg,real-time fluorescent quantification PCR technology was used to detect HBV-DNA,and automatic biochemical analyzer to determine serum ALT level of the patients.At last,comparative analysis of the correlation between them.Results：The level of HBsAg has a positive correlation with HBV-DNA,HBV-DNA has a certain positive correlation with ALT.But the HBsAg level in the serum of patients with hepatitis B and ALT have no obvious correlation.Conclusion：Combining detection for many indicators of hepatitis B patients can help to judge the virus infection,replication,infectivity and the body＇s immunity.