阻塞性睡眠呼吸暂停低通气综合征与冠心病关系的随访研究

Investigation Follow-up Obstructive Sleep Apnea hypopnea Syndrome and Coronary Heart Disease of the Relationship

目的调查随访阻塞性睡眠呼吸暂停低通气综合征(OSAHS)与冠心病的关系。方法对1989年11月至2013年11月1 868例人群进行前瞻性随访,通过家访式调查,随访期间每年进行1次体检,检查血压、血脂、血糖、心电图及X线胸片等,发现存在冠心病表现时为随访终点,随访时间为24年。结果 1 868例中男956例,女912例。其中确诊OSAHS者598(32.0%)例,1 270(68.0%)例无OSAHS(对照组)。随访终点冠心病OSAHS组362(60.5%)例、对照组383(30.2%,P<0.01)例,冠心病的常见类型:心力衰竭、心律失常、心绞痛、心肌梗死、死亡,OSAHS组均较对照组显著增多(P<0.01)。结论长期随访显示,OSAHS患者发生冠心病较一般人群高,考虑OSAHS与发生冠心病存在相关性,可能是冠心病的独立危险因素。

Objective Investigation follow-up obstructive sleep apnea hypopnea syndrome （ OSAHS ） and coronary heart disease of the relationship.Methods In November 1989 to November 2013,1 868 cases of prospective follow-up crowd, through the family visit type survey,the follow-up period 1 year medical examination,check the blood pressure,blood fat,sugar, electrocardiogram and X-ray chest radiograph,found coronary heart disease performance for follow-up end point,followed up for 24 years.Results Among the 1 868 cases of 956 cases of male,female in 912 cases.The diagnosis of OSAHS 598（32.0%）pa-tients,1 270（68.0%）were no OSAHS（control group）.The patients who developed into coronary heart disease were 326/598 （60.5%）in OSAHS group,and383/1 270（30.2%）,P〈0.01）in non-OSAHS group,respectively.Common types of coronary heart disease：heart failure,arrhythmia,angina,myocardial infarction,death,OSAHS group than in the control group was significantly in-creased（P〈0.01）.Conclusion The long-term follow-up,in patients with coronary disease OSAHS effort likely more average crowd high,consider OSAHS and the correlation between coronary disease.24years of follow-up tip OSAHS may be independent risk factors for coronary heart disease.