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IDH1突变在胶质瘤发生发展及改善预后中的作用 被引量：3

Role of isocitrate dehydrogenase 1 mutation in occurrence, development and improving prognosis of gliomas
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摘要 胶质瘤是最常见的颅内原发性肿瘤．起源于神经胶质细胞，占神经上皮肿瘤约60％，具有发病率、复发率、死亡率高和治愈率低的“三高一低”的特点。目前临床治疗方式主要还是手术切除、术后辅以放化疗。虽然最近20年对于胶质瘤的研究取得了长足的进展，但治疗效果仍不甚理想。随着肿瘤分子生物学的研究进展，个体化的基因与分子靶向性治疗越来越受到重视。
作者 何明亮 李凯舒 刘安民
机构地区 中山大学附属孙逸仙纪念医院神经外科
出处 《中华神经医学杂志》 CAS CSCD 北大核心 2015年第12期1215-1219,共5页 Chinese Journal of Neuromedicine
关键词 神经胶质瘤 异柠檬酸脱氢酶1 预后 Glioma Isocitrate dehydrogenase 1 Prognosis
分类号 R739.4 [医药卫生—肿瘤]
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参考文献41

  • 1Parsons DW, Jones S, Zhang X, et al. An integrated genomic analysis of human glioblastoma multiforme [J]. Science, 2008, 321 (5897): 1807-1812.
  • 2Yah H, Parsons DW, Jin G, et al. IDH1 and IDH2 mutations in gliomas [J]. N Engl J Med, 2009, 360(8): 765-773.
  • 3Balss J, Meyer J, Mueller W, et al. Analysis of the IDH1 codon 132 mutation in brain tumors [J]. Acta Neuropathol, 2008, 116 (6): 597-602.
  • 4Bleeker FE, Lamba S, Leenstra S, et al. IDH1 mutations at residue p.R132 (IDH1 (R132)) occur frequently in high-grade gliomas but not in other solid tumors [J]. Hum Mutat, 2009, 30(1): 7-11.
  • 5Watanabe T, Nobusawa S, Kleihues P, et al. IDH1 mutations are early events in the development of astrocytomas and oligodendrogliomas [J]. Am J Pathol, 2009, 174(4): 1149-1153.
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  • 8Geisbrecht BV, Gould SJ. The human PICD gene encodes a cytoplasmic and peroxisomal NADP (+)-dependent isocitrate dehydrogenase [J]. J Biol Chem, 1999, 274(43): 30527-30533.
  • 9Lee SM, Koh HJ, Park DC, et al. Cytosolic NADP(+)-dependent isocitrate dehydrogenase status modulates oxidative damage to cells [J]. Free Radic Biol Med, 2002, 32(11): 1185-1196.
  • 10Kim SY, Lee SM, Tak JK, et al. Regulation of singlet oxygen-induced apoptosis by cytosolie NADP+-dependent isocitrate dehydrogenase [J]. Mol Cell Biochem, 2007, 302(1-2): 27-34.

同被引文献27

  • 1Parsons DW, Jones S, Zhang X, et al. An integrated genomic analysis of human glioblastoma multiforme[J]. Science, 2008, 321 (5897): 1807-1812. DOI: 10.1126/science.1164382.
  • 2Odia Y, Varma H, Tsankova NM. Biphasic IDH1 phenotype in a diffusely infiltrating glioma: implications for pathogenesis, treatment and prognosis [J]. Clin Neuropathol, 2015, 34 (5): 282-287. DOI: 10.5414/NP300832.
  • 3Zhang CB, Bao ZS, Wang HJ, et al. Correlation of IDH1/2 mutation with clinicopathologic factors and prognosis in anaplastic gliomas: a report of 203 patients from China [J]. J Cancer Res Clin Oncol, 2014, 140(1): 45-51.1901: 10.1007/s00432-013-1519-9.
  • 4Wang JB, Dong DF, Wang MD, et al. IDH1 overexpression induced chemotherapy resistance and IDH1 mutation enhanced chemotherapy sensitivity in Glioma cells in vitro and in vivo [J]. Asian Pac J Cancer Prey, 2014, 15(1): 427-432. DOI: 10.7314/APJ- CP.2014.15.1.427.
  • 5Wang XW, Labussiere M, Valable S, et al. IDHI (R132H) mutation increases U87 glioma cell sensitivity to radiation therapy in hypoxia[J]. Biomed Res Int, 2014, 2014: 198697. DOI: 10.1155/ 2014/198697.
  • 6Cui D, Ren J, Shi J, et al. R132H mutation in IDH1 gene reduces proliferation, cell survival and invasion of human glioma by downregulating Wnt/beta-catenin signaling[J]. Int J Biochem Cell Biol, 2016, 73: 72-81. DOI: 10.1016/j.biocel.2016.02.007.
  • 7Catteau A, Girardi H, Monville F, et al. A new sensitive PCR assay for one-step detection of 12 IDH1/2 mutations in glioma [J]. Acta Neuropathol Commun, 2014, 2: 58. DOI: 10.1186/2051-5960-2-58.
  • 8Li J, Zhang H, Wang L, et al. Comparative study oflDH1 mutations in gliomas by high resolution melting analysis, immunohistochemistry and direct DNA sequencing [J]. Mol Med Rep, 2015, 12(3): 4376-4381. DOI: 10.3892/mmr.2015.3987.
  • 9Zou Y, Bai HX, Wang Z, et ak Comparison ofimmunohistochemistry and DNA sequencing for the detection of IDHI mutations in gliomas[J]. Neuro Oncol, 2015, 17(3): 477-478. DOI: 10.1093/ nenonc/nou351.
  • 10Cai J, Zhu P, Zhang C, et al. Detection of ATRX and IDH1-R132H immunohistochemistry in the progression of 211 paired gliomas[J]. Oncotarget, 2016, 7(13): 16384-16395. DOI: 10.18632/oncotarget. 7650.

引证文献3

二级引证文献11

中华神经医学杂志
2015年 第12期

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