幽门螺杆菌感染与2型糖尿病的相关性研究

Association between Helicobacter pylori infection and type 2 diabetes mellitus

目的探讨幽门螺杆菌（H．pylori）感染与2型糖尿病（T2DM）之间的关系。方法以2010年1月至2012年6月于武汉市同济医院体检的2050例人群为研究对象，对其进行人口学特征、空腹血糖、糖化血红蛋白等生化代谢指标进行横断面分析。通过。4c呼气试验诊断是否感染H．pylori，分为HpyZori感染组和1-1．pylori阴性组，分析H．pylori感染与T2DM的关系。结果H．pylori感染组较H．pylori阴性组人群T2DM患病率增高（15．14％：12．06％，存4．08，P〈0．05）。按性别、年龄、体质指数分别进行分层分析，发现在≥45岁人群中，H．pylori感染组较Hpylori阴性组T2DM患病率升高（18．08％：13．57％，χ2=4．09，P〈0．05）。多因素Logistic回归分析显示，校正年龄、性别后，Hpylori与T2DM发病呈正相关（OR=I．349，95％CI：1．021～1．783）：进一步校正吸烟、饮酒、高血压、冠心病、血脂异常、体质指数等混杂因素后，关联性减弱（OR=1．333，95％CI：1．010～1．776）；再增加校正WBC水平后，显著性完全消失（OR=1．261，95％CI：0．943-1．678）。结论中老年人群中．H．pylori感染者较无H．pylori感染者T2DM患病率增加。

Objective To assess the association between H. priori infection and type 2 diabetes mellitus （T2DM）. Methods We conducted cross-sectional analysis on 2 050 subjects who received health examination from January 2010 to June 2012 in Tongji Hospital of Wuhan by using data of demographic characteristics and blood biochemical metabolism index such as fasting blood-glucose, glucosylated hemoglobin, etc. By 14C-Urea Breath Test （14C-UBT）, the participants were divided into H. priori infection group and H. priori negative group to analyze the relationship between H.pylori infection and T2DM. Results The H. priori infection group had significantly higher morbidity of T2DM than H. priori negative group （ 15.14% vs 12.06%, ）（2=4.08, P〈0.05 ）. The subjects were divided into different groups by gender, age and BMI, the morbidity of T2DM was higher in H. priori positive subjects than in H. priori negative subjects in ≥ 45 year-old group （18.08% vs 13.57%, χ2=4.09,P〈0.05）. Multivariable logistic regression was used for further analysis. After adjustment for age and gender, H. priori infection was positively associated with T2DM morbidity （OR=1.349, 95%CI： 1.021-1.783）. The association was attenuated after additional adjustment for smoking, drinking, hypertension, coronary heart disease, dyslipidemia and BMI （OR=1.333, 95%CI： 1.010-1.776）. Furthermore, the association was disappeared after additional adjustment for white blood cell （WBC） level （OR =1.261, 95% CI： 0.943-1.678）. Conclusions The H. priori infection group has significantly higher prevalence of T2DM than H. priori negative group in middle-aged and elderly subjects.