不同年龄子宫肌瘤患者全子宫或次全子宫切除术后卵巢功能的改变

Changes of ovarian function after panhysterectomy or subtotal hysterectomy in the patients with uterine fibroid in different age groups

目的探讨不同年龄的子宫肌瘤患者全子宫或次全子宫切除术后卵巢功能的改变。方法收集我院妇科2012年1月-2013年12月共计80例因子宫肌瘤行全子宫或次全子宫切除术的患者作为研究对象。按患者年龄分为两组,高年龄组32例和低年龄组48例。选择在月经周期第10天左右进行全子宫或次全子宫切除术,术前1天查血促卵泡激素、雌二醇。术后12个月时复查血E2、FSH,取平均值,采血时间定于预期的卵泡晚期。比较两组患者术前、术后12个月时血E2、FSH以及术后是否出现潮热、心慌、失眠的更年期表现。结果高年龄组术前及术后促卵泡激素、雌二醇水平与低年龄组差异无统计学意义（P〉0.05）;高年龄组术后潮热、心慌、失眠的更年期表现例数分别为2例、3例、1例,低年龄组术后潮热、心慌、失眠的更年期表现例数分别4例、2例、2例,两组潮热、心慌、失眠例数差异无统计学意义（P〉0.05）。结论不同年龄子宫肌瘤患者无论全子宫或次全子宫切除术后,对卵巢功能的影响改变不大。

Objective To explore the changes of ovarian function after panhysterectomy or subtotal hysterectomy in the patients with uterine fibroid in different age groups. Methods A total of 80 patients who were given panhysterectomy or subtotal hysterectomy due to uterine fibroid in the Department of Gynecology in our hospital from January 2012 to December 2013 were selected as research subjects. The patients were assigned to two groups according to their ages, with32 patients in high age group and 48 patients in low age group. Panhysterectomy or subtotal hysterectomy were carried out on the 10 th day of menstrual cycle, and follicle-stimulating hormone and estradiol were tested one day before the surgery. E2 and FSH were retested 12 months after the surgery, and the average value was calculated. The blood collection time was confirmed in the predetermined late follicular phase. E2 and FSH before the surgery and 12 months after the surgery were compared between the two groups. Whether menopausal conditions such as hot flash, being flustered and insomnia were detected after the surgery. Results FSH and E2 levels before and after the surgery in the high age group were not statistically different from those in the low age group（P〉0.05）; the number of cases with menopausal conditions such as hot flash, being flustered and insomnia after the surgery in the high age group was 2 cases, 3 cases and 1 case respectively, and the number of cases with menopausal conditions such as hot flash, being flustered and insomnia after the surgery in the low age group was 4 cases, 2 cases and 2 cases respectively. The differences of the number of cases of hot flash, being flustered and insomnia between two groups were not statistically significant（ P 0.05）.Conclusion The effects of panhysterectomy or subtotal hysterectomy on ovarian function are not significant in the patients with uterine fibroid in different age groups.