金双歧联合三联疗法根除幽门螺杆菌疗效观察

Curative effect observation of Jinshuangqi combined with triple therapy for eradication of Helicobacter pylori

目的观察金双歧联合三联疗法治疗幽门螺杆菌（Hp）的临床疗效。方法选择2013年1月-2014年12月收治的214例Hp阳性患者随机分为A组和B、C组：A组予埃索美拉唑、克拉霉素、奥硝唑治疗;B组在此基础上同时加用金双歧;C组在三联疗法后加用金双歧。观察治疗后Hp根除率及不良反应发生率,并进行对比分析。结果 B、C组的Hp根除率分别为90.4%、90.0%,与A组比较,差异有统计学意义（P〈0.05）,B组的不良反应发生率低于A组与C组（P〈0.05）。结论金双歧联合三联疗法治疗Hp感染疗效确切,能提高Hp的根除率,减少不良反应。

Objective To observe the effect of Jinshuangqi combined triple therapy in treatment of Helicobacter pylori（Hp）. Methods 214 Hp positive patients were randomly divided into group A and group B and C from Jan 2013 to Dec 2014. The group A was treated with esomeprazole,clarithromycin,Ornidazole. The group B used the same drugs like group A but added Jinshuangqi at the same time. The group C used the Jinshuangqi after triple therapy. The Helicobacter pylori（Hp） eradicate rate and incidence of adverse reaction rate after treatment were contrasted and analyzed. Results Compared with group A,group B and C＇s the eradication rates were 90.4%,90.0%,and the difference was statistically significant（P〈0.05）; The incidence of adverse reaction rate in group B was lower than the group A and group C（P〈0.05）. Conclusion Jinshuangqi combined with triple therapy has certainly curative effect in the treatment of Hp infection. It can improve the Hp eradicate rate and reduce adverse reaction.