摘要
目的探讨TNF-α和IL-1β对新生儿缺血缺氧性脑病的临床诊断价值。方法 2013年1月~2014年5月收集我院新生儿科的住院新生儿50例,作为缺血缺氧性脑病组。对照组为同期正常出生的足月新生儿50例。分别比较缺血缺氧性脑病组和对照组在出生1 d及出生后7 d血清中TNF-α和IL-1β。结果 1缺血缺氧性脑病组与对照组出生1 d及出生后7 d血清中TNF-α及IL-1β明显高于对照组,差异有统计学意义（P〈0.05）;2缺血缺氧性脑病组中死亡的患儿TNF-α和IL-1β水平明显高于存活者（P〈0.05）。结论 TNF-α和IL-1β能够较好地反映新生儿缺血缺氧性脑病的程度,发生缺血缺氧性脑病死亡的患儿,体内TNF-α和IL-1β明显高于未发生死亡的患儿,TNF-α和IL-1β对诊断缺血缺氧性脑病有较高的临床价值。
Objective To investigate the clinical diagnostic value of TNF-and IL-1 in neonatal hypoxic ischemic encephalopathy. Methods A total of 50 patients with neonatal department of our hospital were collected from January2013 to May 2014（HIE group）. The control group（50 cases） was term newborns with normal birth. IL-1β and TNF-αwere compared between the control group and at 1 day and 7 days after birth. Results（1）The serum levels of IL-1βand TNF-α were significantly higher than those of the control group, and the difference was statistically significant（P〈0.05）.（2）The TNF-α and IL-1β levels in the death of the HIE group were significantly higher than those of the surviving children（P〈0.05）. Conclusion TNF-α and IL-1β can better respond to neonatal hypoxic ischemic encephalopathy,and TNF-α and IL-1β in the IL-1 and IL-1 are higher than those in the patients with hypoxic ischemic encephalopathy.
出处
《中国现代医生》
2015年第34期58-60,共3页
China Modern Doctor
