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阿尔茨海默病的危险因素 被引量:5

Risk factorsfor Alzheimer’s disease
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摘要 近年来研究发现,阿尔茨海默病( AD)和其他慢性疾病一样,并非由单一因素引起,而是多种危险因素相互作用的共同结果。本文整理了可使AD发病风险增加的一些因素,包括高龄、吸烟、基因突变、APOE-ε4基因、心脑血管疾病、2型糖尿病和颅脑损伤等。探讨其在AD发生发展中的作用,为AD的防治工作奠定基础。 Recent researches show that Alzheimer’sdisease (AD), like other common chronic diseases, develops as a result ofinteraction ofmultiple factors rather than a single cause. This article reviewed some factors that can increase the risk of AD, such as age, smoke, genetic mutations,apolipoprotein E(APOE)-ε4 gene, cardiovascular and cerebrovascular diseases, type 2 diabetes mellitus and traumatic brain injury. We aimedto discuss theirroles in the development of AD,andthus provide a foundation for prevention and treatment of AD.
作者 王越 拓西平
出处 《中华老年多器官疾病杂志》 2015年第11期873-876,共4页 Chinese Journal of Multiple Organ Diseases in the Elderly
基金 上海市卫生和计划生育委员会科研重点项目(201440022)
关键词 阿尔茨海默病 基因突变 血管疾病 高血压 颅脑损伤 Alzheimer’sdisease genetic mutation vascular diseases hypertension traumatic brain injury
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