摘要
近年来研究发现,阿尔茨海默病( AD)和其他慢性疾病一样,并非由单一因素引起,而是多种危险因素相互作用的共同结果。本文整理了可使AD发病风险增加的一些因素,包括高龄、吸烟、基因突变、APOE-ε4基因、心脑血管疾病、2型糖尿病和颅脑损伤等。探讨其在AD发生发展中的作用,为AD的防治工作奠定基础。
Recent researches show that Alzheimer’sdisease (AD), like other common chronic diseases, develops as a result ofinteraction ofmultiple factors rather than a single cause. This article reviewed some factors that can increase the risk of AD, such as age, smoke, genetic mutations,apolipoprotein E(APOE)-ε4 gene, cardiovascular and cerebrovascular diseases, type 2 diabetes mellitus and traumatic brain injury. We aimedto discuss theirroles in the development of AD,andthus provide a foundation for prevention and treatment of AD.
出处
《中华老年多器官疾病杂志》
2015年第11期873-876,共4页
Chinese Journal of Multiple Organ Diseases in the Elderly
基金
上海市卫生和计划生育委员会科研重点项目(201440022)
关键词
阿尔茨海默病
基因突变
血管疾病
高血压
颅脑损伤
Alzheimer’sdisease
genetic mutation
vascular diseases
hypertension
traumatic brain injury