己酮可可碱治疗2型糖尿病性肾病的临床效果观察

Clinical Effect Observation of Pentoxyfylline in the Treatment of Type 2 Diabetic Nephropathy

目的探讨己酮可可碱(PTF)治疗2型糖尿病性肾病的临床疗效。方法选取我院2013年6月至2015年6月收治2型糖尿病性肾病患者88例为研究对象,按照随机数字表法分为研究组和对照组各44例。研究组患者给予己酮可可碱片治疗,对照组患者不给予任何药物治疗。观察并比较两组患者治疗后的血粘度、血浆白蛋白、尿视黄醇结合蛋白及24小时尿蛋白检测结果。结果研究组患者经4个月己酮可可碱治疗后的血浆粘度、全血低切粘度、全血高切粘度均明显低于对照组,组间差异有统计学意义(P<0.05)。研究组患者治疗后的24小时尿蛋白、血浆白蛋白、尿视黄醇结合蛋白均明显低于对照组,组间差异有统计学意义(P<0.05)。结论对2型糖尿病性肾病患者采用己酮可可碱治疗可以有效降低患者高血粘度状态、24小时尿蛋白及尿系列微量蛋白,还可预防肾功能衰竭的发展,因而值得临床推广。

Objective To investigate the clinical effect ofpentoxifylline （PTF） in the treatment of type 2 diabetic nephropathy （DN）. Methods 88 cases of patients with type 2 diabetic nephropathy treated in our hospital from June 2013 to June 2015 were selected and divided into study group and control group according to the random number table, with 44 cases in each group. The study group was treated with pentoxifylline, while the control group wasn＇t given any drug therapy. The detection results of blood viscosity, plasma albumin, retinol binding protein and 24-hour urinary protein were observed and compared between two groups. Results The plasma viscosity, low shear blood viscosity, high shear blood viscosity of study group after 4 months of pentoxifylline therapy were significantly lower than those of control group, with statistical difference （P〈0.05）. The 24-hour urinary protein, plasma albumin, retinol binding protein of study group after treatment were significantly lower than those of control group, with statistical difference （P〈0.05）. Conclusions For patients with type 2 diabetic nephropathy, pentoxifylline can effectively reduce patients＇ high blood viscosity, 24-hour urinary protein and urinary series microprotein, prevent the development of renal failure, which deserves promotion in clinic.