利培酮与阿立哌唑治疗儿童抽动障碍的随机对照研究

A randomized controlled study of risperidone and aripiprazole in treatment of children with tic disorder

目的探讨利培酮与阿立哌唑治疗儿童抽动障碍的临床效果。方法选取我院就诊的儿童抽动障碍患者80例,将其按照数字表法随机分为利培酮组和阿立哌唑组,每组各40例。利培酮组患者采用利培酮治疗,阿立哌唑组应用阿立哌唑治疗。连续治疗12周后,比较两组患儿治疗有效率,采用耶鲁综合抽动严重程度量表(YGTSS)进行疗效的评定和对比,同时观察和记录两组患者不良反应发生情况。结果利培酮组患者治疗的有效率为90.0%(36/40),显效率75.0%(30/40);阿立哌唑组患者治疗的有效率92.5%(37/40),显效率82.5%(33/40)。两组患者治疗的有效率和显效率差异无统计学意义(u=1.776,0.672,P>0.05)。两组患者用药2周和6周后YGTSS评分减分率、运动性抽动评分减少率、发声性抽动评分减少率及全部损害率评分减少率比较差异无统计学意义(P>0.05)。用药12周时阿立哌唑组患者的上述指标改善优于用药2周时(P<0.05)。两组均未出现严重的不良反应,血常规及肝肾功能检查均正常。结论阿立哌唑治疗儿童抽动障碍疗效与利培酮相同,安全性高,值得临床推广。

Objective To compare the clinical effects between risperidone and aripiprazole in the treatment of children with tic disorder.Methods A total of 80 cases of children with tic disorder were randomly divided into A group（40cases）and B group（40cases）.Children with tic disorder in group A were treated by risperidone and children with tic disorder in group B were treated by aripiprazole.After 12 weeks of treatment,the efficacy of the YGTSS score table（Yale comprehensive tic severity scale）was assessed and compared,and the adverse reactions of both groups were observed and recorded.Results The effective rate and significant effective rate in group A were 90%（36/40）and 75%（30/40）,respectively;the effective rate and significant effective rate were 92.5%（37/40）and82.5%（33/40）in group B;there were no significant difference between two groups（u =1.776,0.672,P 〉0.05）.There were no significant difference in YGTSS score reduction fraction,motor tic score reduction rate,sound of tic score reduction rate and total lesion score reduction rate between two groups after 2and 6 weeks＇ treatment（P 〉0.05）.At 12 weeks of treatment,the indicators of YGTSS score reduction fraction,motor tic score reduction rate,sound of tic score reduction rate and total lesion score reduction rate were significantly better than at 2 weeks of treatment（P〈 0.05）.There was no serious adverse reactions in both groups and blood and liver function tests were normal.Conclusion Aripiprazole has significant effect as risperidone in the treatment of children with tic disorder,high security and it is worthy of clinic application.