血清蛋白聚糖-1与糖尿病慢性肾脏疾病的相关性研究

The relationship between serum protein proteoglycans 1 and diabetic chronic kidney disease

目的分析血清蛋白聚糖-1与糖尿病慢性肾脏病变的相关性。方法选取2012年12月—2014年12月收治的无微量白蛋白尿2型糖尿病(NMALB组)和微量白蛋白尿2型糖尿病(MALB组)患者,各100例,另选取50例正常人作为健康对照组,检测并比较3组患者空腹血糖(FPG)、尿素(BUN)、血肌酐(SCr)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白—胆固醇(HDL-C)、低密度脂蛋白—胆固醇(LDL-C)、极低密度脂蛋白—胆固醇(VLDL-C)、糖化血红蛋白(HbA_(1c))和血清蛋白聚糖-1。结果与健康对照组比较,NMALB组和MALB组FPG、BUN、SCr、TG、VLDL均升高,HDL-C降低(q=3.42、10.01,2.89、8.38,10.15、14.38,8.55、10.82,8.08、10.69,4.73、8.40,P均<0.01或P<0.05);MALB组FPG、BUN、SCr均高于NMALB组,HDL-C低于NMALB组(q=6.93、44.41、5.18、4.48,P均<0.01或P<0.05)。NMAL.B组和MALB组血清蛋白聚糖-1均显著高于健康对照组(t=4.27、9.25,P<0.01);MALB组血清蛋白聚糖-1显著高于NMALB组(t=10.36,P<0.01)。尿微量白蛋白和血清蛋白聚糖-1呈正相关(r^2=0.343,P<0.01)。结论糖尿病患者血清蛋白聚糖-1与尿微量白蛋白呈正相关,可作为糖尿病肾损伤的早期检测指标。

Objective To analyze the relationship between the serum protein proteoglycans 1 and diabetic chronic kidney disease.Methods From December 2012 to December 2014,selected the patients who admitted to department of endocrinology,they were divided into non-microalbuminuria in type 2 diabetes（NMALB group） and microalbuminuria in type 2diabetes（MALB group） patients,100 cases in each group,50 cases of normal healthy were selected as control group,fasting plasma glucose（FPG）,blood urea nitrogen（BUN）,serum creatinine（SCr）,total cholesterol（TC）,triglyceride（TG）,high density lipoprotein cholesterol（HDL-C）,low density lipoprotein cholesterol（LDL-C）,very low density lipoprotein cholesterol（VLDL-C）,glycated hemoglobin（HbA_（1c）） anil serum proteoglycans 1 were detected and compared among the three groups of patients.Results Compared with the healthy control group,NMALB and MALB group＇s FPG,BUN,SCr,TG,VLDL-C were increased,HDL-C were decreased（q = 3.42,q =10.01,q=2.89,q =8.38,q =10.15,q =14.38,q =8.55.q = 10.82,q =8.08,q =10.69,q =4.73,q =8.40.P〈0.01 or P〈0.05）;MALB group＇s FPG,BUN and SCr were higher in NMALB group,HDL-C were lower than NMALB group（q =6.93,q =44.41,q =5.18,5 =4.48,P〈0.01 or P〈0.05）.NMALB group and MALB group＇s serum levels of proteoglycans 1 were significantly higher than those in healthy control group（t =4.27,t =9.25,P〈0.01）;MALB group＇s serum level of proteoglycans 1 was significantly higher than NMALB group（t = 10.36,P〈0.01）.Urine albumin and serum protein proteoglycans were positively correlated（r = 0.343,P〈0.01）.Conclusion Serum proteoglycan 1 and microalbuminuria was positive correlated,it can be used as early detection indicator for diabetic kidney injury.