RAU临床特征与血清免疫球蛋白及补体水平的关系

The relationship between clinical characteristics and serum immunoglobulin and complement in recurrent aphthous ulcer

目的:探讨复发性阿弗他溃疡(RAU)临床特征与血清中体液免疫指标的关系。方法:观察记录85例RAU患者的性别、年龄、临床分型和溃疡面积等临床特征,采用免疫散射比浊法检测患者外周血血清中免疫球蛋白IgA、IgG、IgM、IgE和补体C3、C4的水平,分析各临床特征与血清中体液免疫水平之间的关系。结果:1性别分组,RAU患者的血清免疫球蛋白及补体水平的差异无统计学意义(P>0.05)。2年龄分组,≥50岁组RAU患者血清IgA的水平显著高于<50岁组(P<0.05)。3临床分型,重型RAU组的血清C3水平显著高于轻型RAU组(P<0.05)。4溃疡面积,≥0.5 cm^2组的血清C3水平明显高于<0.5 cm^2组(P<0.05)。结论:RAU患者亚群的血清免疫球蛋白及补体水平存在差异,可能与年龄、临床分型、溃疡面积等临床特征密切相关。

Objective： The objective of the study was to investigate the relationship between clinical characteristics and humoral immunity in recurrent aphthous ulcer （RAU）. Method： The clinical characteristics of 85 RAU patients were recorded, including gender, age, clinical typing and area of ulcer. The serum levels of IgA, IgG, IgM, IgE, C3 and C4 from peripheral blood of these RAU patients were assayed by immunoturbidimetry. The correlation between serum levels of IgA, IgG, IgM, IgE, C3 and C4 and clinical characteristics was analyzed statistically. Result： There was no statistically signifi- cant difference of serum immunoglobulins and complements between male and female patients. The serum level of IgA in RAU patients with the age ≥ 50 was significantly higher than that in RAU patients with the age 〈50 （P〈 0.05）. According to clinical typing, the serum level of C3 in RAU patients with major type was significantly higher than that in RAU patients with minor type （P〈 0.05）. The serum level of C3 in RAU patients with area of ulcer ≥ 0.5 cm2 was significantly higher than that in RAU patients with area of ulcer 〈0.5 cm2 （P〈 0.05）. Conclusion： There are differential levels of seroimmunity be- tween various subgroups of RAU patients, which are closely related to clinical characteristics, such as age, clinical typing and area of ulcer.