心血管系统电网络模型的脉动信号仿真分析

Simulation Analysis of the Pulse Signal on the Electricity Network of Cardiovascular System

脉搏波蕴含了人体丰富的生理病理信息,研究脉搏波与心血管系统生理参数的关系不但有利于心血管疾病的临床诊断与治疗,而且有助于新型医疗设备的开发。本文在经典双弹腔模型的基础上,采用电网络模型法建立了人体心血管仿真系统,对动脉内血压与血流的变化规律进行仿真,分析了外周阻力与血管顺应性对血流分布的影响,并将仿真结果与临床监测结果进行对比分析,以预测人体的生理病理状态。结果表明,血压与血流的仿真波形于第二个心动周期后逐渐趋于稳定;随着外周阻力的增大,动脉的收缩压增大,舒张压保持不变,而脉压逐渐增大;随着血管顺应性的减小,血管的弹性变差,脉压相应地增大;仿真结果与临床监测结果一致。外周阻力增大和血管顺应性减小预示了高血压和动脉粥样硬化等疾病的发生率增大。

Pulse waves contain abundant physiological and pathological information of human body. Research of the relationship between pulse wave and human cardiovascular physiological parameters can not only help clinical diagno- sis and treatment of cardiovascular diseases, but also contribute to develop many new medical instruments. Based on the traditional double elastic cavity model, the human cardiovascular system was established by using the electric net- work model in this paper. The change of wall pressure and blood flow in artery was simulated. And the influence of the peripheral resistance and vessel compliance to the distribution of blood flow in artery was analyzed. The simula- tion results were compared with the clinical monitoring results to predict the physiological and pathological state of human body. The result showed that the simulation waveforrn of arterial wall pressure and blood flow was stabile af ter the second cardiac cycle. With the increasing of peripheral resistance, the systolic blood pressure of artery in- creased, the diastolic blood pressure had no significant change, and the pulse pressure of artery increased gradually. With the decreasing of vessel compliance, the vasoactivity became worse and the pulse pressure increased correspond- ingly. The simulation results were consistent with the clinical monitoring results. The increasing of peripheral resist- ance and decreasing of vascular compliance indicated that the incidence of hypertension and atherosclerosis was in- creased.