质子转移反应质谱在呼气检测领域的研究进展

Research Progress of Proton Transfer Reaction Mass Spectrometry in the Field of Breathing Gas Detection

人体呼出的气体携带有重要的生理信息,而呼出气体检测技术具有采样无损、操作便利等优点,是医疗检测领域的研究热点。质子转移反应质谱(PTR-MS)因灵敏度高、响应速度快、特异性好等优点,在呼出气体检测领域发挥着不可替代的作用。本文介绍了PTR-MS的基本原理,综述了PTR-MS在呼出气体检测领域的研究进展,分析了影响测量结果的主要因素,并对其发展方向进行了展望。

Breathing gas carries important physiological information. Technology for detection of breathing gas has become a research focus because of the advantages of nondestructive sampling and convenient operation. Proton transfer reaction mass spectrometry （PTR-MS） plays an irreplaceable role because of the advantages of high sensitivity, fast response and good specificity. In this paper, the principle of PTR-MS is introduced first, followed by research progress of PTR-MS in the field of breathing gas detection. Factors influencing the test results are analyzed. Finally, future prospects of development for PTR MS in the field of breathing gas detection are discussed.