摘要
人体呼出的气体携带有重要的生理信息,而呼出气体检测技术具有采样无损、操作便利等优点,是医疗检测领域的研究热点。质子转移反应质谱(PTR-MS)因灵敏度高、响应速度快、特异性好等优点,在呼出气体检测领域发挥着不可替代的作用。本文介绍了PTR-MS的基本原理,综述了PTR-MS在呼出气体检测领域的研究进展,分析了影响测量结果的主要因素,并对其发展方向进行了展望。
Breathing gas carries important physiological information. Technology for detection of breathing gas has become a research focus because of the advantages of nondestructive sampling and convenient operation. Proton transfer reaction mass spectrometry (PTR-MS) plays an irreplaceable role because of the advantages of high sensitivity, fast response and good specificity. In this paper, the principle of PTR-MS is introduced first, followed by research progress of PTR-MS in the field of breathing gas detection. Factors influencing the test results are analyzed. Finally, future prospects of development for PTR MS in the field of breathing gas detection are discussed.
出处
《生物医学工程学杂志》
CAS
CSCD
北大核心
2015年第6期1374-1379,共6页
Journal of Biomedical Engineering
基金
国家重大科学仪器设备开发专项基金资助(2013YQ090875-2,2013YQ090875-7)
关键词
呼出气体检测
质子转移反应质谱
易挥发有机化合物
呼气标志物
breathing gas detection
proton transfer reaction mass spectrometry, volatile organic compounds
breathbiomarker