群体药代动力学用于丙戊酸钠个体化给药

Population pharmacokinetics in individualized drug dosage regimes of valproate

丙戊酸钠是目前临床上最常用的广谱抗癫疒间药物。其治疗窗窄,体内代谢受多种因素的影响,不同个体间差异较大,临床需对其进行个体化给药。群体药代动力学是近年来发展迅速的一种药代动力学的群体分析方法。本文对近年来丙戊酸钠体内代谢过程和群体药代动力学研究及应用作一综述,分析归纳影响丙戊酸钠代谢的可能因素,如人口学特征、合并用药及遗传因素等,从而为临床个体化给药提供参考。

Valproate is commonly used as a first-line broad-spectrum anti-epileptic drug.Valproate has a narrow therapeutic window,its metabolism is affected by many factors,and it has great individual differences,which makes individualized drug dosage regime needed for valproate.Population pharmacokinetics is a population analytical method developed in recent years.This paper reviewed the in vivo metabolic process and the population pharmacokinetics of valproate in recent years,and analyzed the factors that may affect the metabolism of valproate,including demographic factors,genetic factors and concomitant medications,hoping to provide reference for clinical individualized drug dosage regime.