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MicroRNA与肌肉萎缩 被引量：2

MicroRNA and muscle atrophy:recent progress
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摘要 MicroRNA(miRNA)在转录后水平参与多种基因的表达调控,在诸多生理活动与病理过程中发挥重要作用。越来越多的证据表明,肌肉萎缩类疾病涉及miRNA调控,是该类疾病潜在的诊断标记物和药物治疗靶点。本文就肌肉萎缩与miRNA相关研究进展作一综述,为肌肉疾病的预防和治疗提供理论依据。 MicroRNA（miRNA）is involved in the regulation of many genes at the post-transcriptional level and plays an important role in many physiological and pathological processes.More and more evidence suggests that muscle atrophy diseases are related to the regulation of miRNA,which indicting that miRNA may have a great potential to become biomarkers and drug targets for the treatment and diagnosis of the disease.This paper outlined the progress of miRNA in muscle atrophy,hoping to provide a theoretical basis for the prevention and treatment of muscle diseases.
作者 余日臻 许静
机构地区 第二军医大学长海医院肾内科
出处 《第二军医大学学报》 CAS CSCD 北大核心 2015年第12期1339-1343,共5页 Academic Journal of Second Military Medical University
基金 国家自然科学基金(81470970)~~
关键词 微RNAS 萎缩性肌疾病 发病机制 治疗学 microRNAs atrophic muscular disorders pathogenesis therapeutics
分类号 R685.5 [医药卫生—骨科学]
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  • 1Bartel D P. MicroRNAs: genomics, biogenesis, mechanism, and function[J].Cell, 2004, 116:281-297.
  • 2Eisenberg I, Eran A, Nishino I, Moggio M, Lamperti C, Anthony A A, et al. Distinctive patterns of microRNA expression in primary muscular disorders[J].Proc Natl Acad Sci USA, 2007, 104:17016-17021.
  • 3Greco S, De Simone M, Colussi C, Zaccagnini G, Fasanaro P, Pescatori M, et al. Common micro-RNA signature in skeletal muscle damage and regeneration induced by Duchenne muscular dystrophy and acute ischemia[J]. FASEB J, 2009, 23: 3335-3346.
  • 4Zaharieva I T, Calissano M, Scoto M, Preston M, Cirak S, Feng L, et al. Dystromirs as serum biomarkers for monitoring the disease severity in Duchenne muscular dystrophy[J]. PLoS One, 2013, 8:e80263.
  • 5Cacchiarelli D, Legnini I, Martone J, Cazzella V, D'Amico A, Bertini E, et al. miRNAs as serum biomarkers for Duchenne muscular dystrophy[J]. EMBO Mol Med, 2011, 3: 258-265.
  • 6Gracia-Iguacel C, Gonzalez-Parra E, Perez-Gomez MV, Mahíllo L, Egido J, Ortiz A, et al. Prevalence of protein-energy wasting syndrome and its association with mortality in haemodialysis patients in a centre in Spain[J]. Nefrologia, 2013, 33:495-505.
  • 7Wang X H, Hu Z, Klein J D, Zhang L, Fang F, Mitch W E. Decreased miR-29 suppresses myogenesis in CKD[J]. J Am Soc Nephrol, 2011, 22:2068-2076.
  • 8Donaldson A, Natanek S A, Lewis A, Man W D, Hopkinson N S, Polkey M I, et al. Increased skeletal muscle-specific microRNA in the blood of patients with COPD[J].Thorax, 2013, 68: 1140-1149.
  • 9Lewis A, Riddoch-Contreras J, Natanek S A, Donaldson A, Man W D, Moxham J, et al. Downregulation of the serum response factor/miR-1 axis in the quadriceps of patients with COPD[J].Thorax, 2012, 67:26-34.
  • 10Chen G Q, Lian W J, Wang G M, Wang S, Yang Y Q, Zhao Z W. Altered microRNA expression in skeletal muscle results from high-fat diet-induced insulin resistance in mice[J].Mol Med Rep, 2012, 5:1362-1368.

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引证文献2

第二军医大学学报
2015年 第12期

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