青龙衣的化学成分

Chemical constituents from pericarp of Juglans mandshurica Maxim

目的研究抗肿瘤植物青龙衣（核桃楸Juglans Mandshurica Maxim未成熟果实的果皮）的化学成分。方法青龙衣提取物采用硅胶柱、制备色谱进行分离纯化,并根据波谱数据鉴定所得化合物的结构。结果从中分离得到14个化合物,分别鉴定为3-甲氧基胡桃醌（1）、3-乙氧基胡桃醌（2）、豆甾-5-烯-3β-醇（3）、豆甾-4-烯-3-酮（4）、（24R）-5α-豆甾烷-3,6二酮（5）、二氢去氢二愈创木基醇（6）、内消旋二氢愈创木脂酸（7）、松柏醇-9-O-β-D-葡萄糖苷（8）、massonianoside D（9）、原儿茶酸甲酯（10）、4-羟甲基-2-甲氧基苯酚（11）、4-羟基-3-甲氧基苯甲醛（12）、原儿茶酸（13）、丁香酸（14）。结论化合物3-9、11-13为首次从胡桃属植物中分离得到,化合物2、10为首次从青龙衣中分离得到。

AIM To study the chemical constituents from an anti-tumor plant—pericarps of Juglans mandshurica Maxim. METHODS The pericarps of J. mandshurica extract was separated and purified by silica and preparative chromatography. The structures of isolated compounds were then elucidated on the basis of spectral data.RESULTS Fourteen compounds were isolated and identified as 3-methoxy juglone（ 1）,3-ethoxy juglone（ 2）,stigmast-5-en-3β-ol（ 3）,stigmast-4-en-3-one（ 4）,24（ R）-5α-stigmastane-3,6-dione（ 5）,（-）-dihydrodehy-drodiconiferyl alcohol（ 6）,mesodihydroguaiaretic acid（ 7）,coniferylalcohol-9-O-β-D-glucopyranoside（ 8）,massonianoside D（ 9）,protocatechuic acid methyl ester（ 10）,4-hydroxymethyl-2-methoxy phenol（ 11）,4-hydroxy-3-methoxybenzene formaldehyde（ 12）,protocatechuic acid（ 13）,syringic acid（ 14）. CONCLUSION Compounds 3-9,11-13 are isolated from genus Juglans for the first time. Compounds 2 and 10 are firstly obtained from this plant.