脑卒中合并深静脉血栓生物标记物的研究进展

The study of molecular markers in stroke patients with deep vein thrombosis

深静脉血栓是一种常见的周围血管疾病,由于其具有较高的发病率、复发率和致死率,已经成为一个重要的公共健康问题。脑卒中患者易合并深静脉血栓形成,严重影响患者的生存率和生活质量,甚至危及生命。近年来,国内外学者在深静脉血栓形成机制,特别是在分子水平进行了大量研究,发现了多种与深静脉血栓形成相关的生物标记物,然而由于遗传和环境因素不同,生物标记物在东、西方人群中存在较大差异。生物标记物有助于早期发现深静脉血栓形成,并采取相应的临床诊断和治疗。本综述着重探讨一些与深静脉血栓相关的生物标记物。

Deep vein thrombosis is a common peripheral vascular disease, it has become an important public health problem due to its high morbidity rate, recurrence rate and fatality rate. Stroke patients prone to merge deep vein throm- bosis,so the survival and quality of life have been greatly affected, and even life-threatening. Recent studies on the patho- genesis of deep vein thrombosis at the molecular level have shown that a variety of molecular markers are associated with deep vein thrombosis, by the scholars at home and abroad. However, the different genetic and environmental factors lead to a big difference in the molecular markers between east and west. Molecular markers are helpful to early detection of deep vein thrombosis and make clinical diagnosis and treatment appropriately. This article will be to summarize of molec- ular markers associated with deep vein thrombosis.