中药保留灌肠联合美沙拉嗪治疗溃疡性结肠炎效果观察

Treating ulcerative colitis in TCM

目的:中药保留灌肠联合美沙拉嗪治疗慢性溃疡性结肠炎的方法及临床疗效。方法:将70例慢性溃疡性结肠炎患者随机分为观察组及对照组各35例,观察组中药保留灌肠同时给予美沙拉嗪1g口服,1次/d;对照组柳氮磺吡啶1g口服,3次/d;奥硝唑1.0加入生理盐水200m L静滴,1次/d。两组疗程均为15d。结果:治疗前两组患者结肠镜检积分比较无显著性差异(P>0.05);治疗后观察组结肠镜检积分降低幅度明显优于对照组,组间比较差异显著(P<0.05)。观察组总有效率为97.1%,对照组为74.3%,组间比较差异显著(P<0.05)。结论:中药保留灌肠联合美沙拉嗪治疗溃疡性结肠炎临床疗效满意,复发率低,且无明显不良反应,适于临床推广使用。

Objective： Clinical efficacy of TCM retention enema plus mesalazine for chronic ulcerative colitis was explored. Methods： 70 patients were randomly divided into two groups. 35 cases in the observation group took TCM retention enema with oral mesalazine; 35 cases in the control group took sulfasalazine and ornidazole. Results： Before the treatment, there was no significant difference （P〉0.05）. By the colonoscopy, after the treatment, the efifcacy in the observation group was better （P〈0.05）. The total efifciency was 97.1%in the observel group and 74.3%in the control group （P〈0.05）. Conclusion：TCM retention enema plus mesalazine treatment for ulcerative colitis were satisfactory.