解毒凉血法治疗乙型肝炎慢加急性肝衰竭的疗效评价及机制研究

Research on clinical evaluation and mechanism for treating acute-on-chronic hepatitis B liver failure by the Jiedu Liangxue therapy

目的:探讨解毒凉血法治疗乙型肝炎慢加急性肝衰竭患者的临床效果。方法:将74例乙型肝炎慢加急性肝衰竭患者分为治疗组和对照组,每组37例。对照组患者采用西医方法治疗,治疗组患者在西医治疗的基础上采用解毒凉血法治疗。结果:治疗20周后,治疗组患者的病死率为21.6%,明显低于对照组患者的37.8%(P<0.05);治疗前两组患者的肝功能比较无明显差异(P>0.05),治疗20周后治疗组患者的肝功能明显优于对照组患者(P<0.05)。结论:在常规西医治疗的基础上应用解毒凉血法治疗乙型肝炎慢加急性肝衰竭可有效改善患者肝功能,降低病死率。

Objective： To investigate clinical effects of the Jiedu Liangxue therapy on acute-on-chronic hepatitis B liver failure. Methods： 74 patients were divided into the treatment group and the control group, 37 cases for each. The control group was treated with western medicine. The treatment group was treated by the Jiedu Liangxue therapy more. Results： In 20 weeks, mortality in the treatment group was 21.6%, much lower than 37.8% in the control group; liver function in the treatment group was much better（P〈0.05）. Conclusion： Treating acute-on-chronic hepatitis B liver failure by the Jiedu Liangxue therapy based on conventional western medicine was effective, could effectively improve liver function, and reduce mortality.