气郁质与平和质的磁共振血氧依赖性脑功能成像研究

Study on BOLD-FMRI functional brain imaging of Qi-stagnation constitution and constitution of yin-yang harmony

目的:探究中医体质学说中气郁质与平和质的磁共振血氧依赖性脑功能成像特点及意义。方法:选取2011年5月—2013年5月20例行头部功能磁共振成像(FMRI)检验的受检者,其中包括平和质12例,气郁质8例,对所有受检者进行全脑解剖像扫描、选定区域功能像扫描,采用情绪图片刺激试验来观察两种体质受检者的FMRI图像变化情况。结果:同组内同一条件下左、右杏仁核激活体积对比有差异,左侧激活体积较右侧大;同组内同侧杏仁核在不同条件下的比较,平和质组在喜悦图片下的激活体积较悲伤图片大,而气郁质组对比无统计学意义;两组间同一条件下左、右杏仁核分别比较,气郁质的双侧杏仁核激活体积均较平和质减低,以喜悦图片下减低明显。结论:FMRI可以对不同中医体质人群的脑功能成像进行定位和定量分析,气郁质、平和质人群脑部均存在一定的激活区,在杏仁核区域的分布较为集中,且气郁质人群的杏仁核在脑功能成像中的激活体积较平和质减低,喜悦图片下激活体积更小。

Objective： To explore the characteristics and significance of BOLD-f MRI Functional Brain Imaging of Qi-stagnation constitution and constitution of yin-yang harmony. Methods： 20 patients, 12 Qi-stagnation constitution patients and 8 patients ofconstitution of yin-yang harmony, were given head functional magnetic resonance imaging（FMRI） in addition to whole brain anatomy image scanning, selected area function image scanning. Results： left and right amygdala activation volume was significantly different in the same group, the outcome of patients of constitution of yin-yang harmony excelled that of i-stagnation constitution patients. Conclusion：FMRI can carry out the localization and quantitative analysis of cerebral functional imaging in different TCM Constitutions.