鸭H5亚型高致病性禽流感疫苗研究进展及其效率影响因素

Vaccines Against Duck H5 Subtype Highly Pathogenic Avian Infl uenza and Factors Infl uencing Its Effi ciency

鸭在H5亚型高致病性禽流感的流行中发挥重要作用,成功控制鸭H5亚型高致病性禽流感对根除该病在家禽中的流行和人类健康具有重要的意义。本文对当前鸭H5亚型高致病性禽流感疫苗使用和研究进展,以及影响疫苗效率的因素(疫苗类型、鸭的品种、免疫程序、疫苗的抗原匹配性、佐剂、免疫覆盖率)进行了综述。

Domestic ducks play an important role in the epidemiology of H5N1 highly pathogenic avian influenza（HPAI） viruses. Consequently,successful control over H5N1 HPAI in ducks is important for the eradication of the disease in poultry and for preventing infections in humans. Here we reviewed the current situation and progresses on duck H5N1 HPAIV vaccines and the factors that influence the efficiency of vaccines,including types of vaccines,duck species,vaccination schedules,homology between vaccine and challenge virus,adjuvants,and vaccination coverage.