离子液体催化合成二十八烷醇硬脂酸酯的研究

Ionic liquid catalyzed synthesis of octacosanol stearate

以离子液体为催化剂,以硬脂酸为修饰剂对二十八烷醇进行修饰合成二十八烷醇硬脂酸酯。通过高效液相色谱、红外光谱和核磁共振波谱对产物进行结构表征,证实所合成产物为目标产物二十八烷醇硬脂酸酯。考察了离子液体种类及用量、反应温度、底物摩尔比及反应时间对产物转化率的影响。结果表明,以1-磺酸丁基-3-甲基咪唑硫酸氢盐([BSO3HMim][HSO4])为催化剂,用量为底物总质量的3%,二十八烷醇与硬脂酸摩尔比1∶1.5,90℃下反应2 h,产物的转化率可达98%。通过DSC分析可知,经硬脂酸酯化修饰后二十八烷醇的熔点有所降低,从84.3℃降至71.2℃,有助于拓宽其实际应用范围。

With ionic liquids （ILs） as catalyst and stearic acid as dressing agent, octacosanol stearate was synthesized by modifying octaeosanol. The product was characterized by HPLC, FFIR and NMR to be confirmed as the target product octacosanol stearate. The influences of the kind and dosage of ILs, reac- tion temperature, molar ratio of substrate and reaction time on the conversion rate of product were stud- ied. The results showed that the conversion rate could reach 98% under the following conditions： with 1 - butylsulfonate - 3 - methylimidazolium hydrogensulfate （ [ BSO3HMim] [ HSO4 ] ） as catalyst, dosage of catalyst 3% （based on the total mass of substrates）, molar ratio of octacosanol to stearic acid 1： 1.5, reaction temperature 90℃ and reaction time 2 h. The DSC analysis result indicated that the melting point of octacosanol decreased from 84.3 ℃ to 71.2 ℃ after esterification with stearic acid, which was helpful to broaden the practical application range of octacosanol.